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Intracytoplasmic morphologically selected sperm injection, but for whom?

Published online by Cambridge University Press:  15 August 2019

Seda Karabulut Open the ORCID record for Seda Karabulut [Opens in a new window] ,
Ozlem Aksunger ,
Oya Korkmaz ,
Hilal Eren Gozel Open the ORCID record for Hilal Eren Gozel [Opens in a new window]  and
Ilknur Keskin
Seda Karabulut*
Affiliation:
Medipol University, School of Medicine, Kavacik, Istanbul, Turkey Medipol University, School of Medicine, REMER (Regenerative and Restorative Medicine Research Centre), Kavacik, Istanbul, Turkey
Ozlem Aksunger
Affiliation:
Memorial Antalya Hospital/IVF Centre, Antalya, Turkey
Oya Korkmaz
Affiliation:
Medipol University, School of Medicine, Kavacik, Istanbul, Turkey Medipol University, School of Medicine, REMER (Regenerative and Restorative Medicine Research Centre), Kavacik, Istanbul, Turkey
Hilal Eren Gozel
Affiliation:
Medipol University, School of Medicine, Kavacik, Istanbul, Turkey Medipol University, School of Medicine, REMER (Regenerative and Restorative Medicine Research Centre), Kavacik, Istanbul, Turkey
Ilknur Keskin
Affiliation:
Medipol University, School of Medicine, Kavacik, Istanbul, Turkey Medipol University, School of Medicine, REMER (Regenerative and Restorative Medicine Research Centre), Kavacik, Istanbul, Turkey
*
Address for correspondence: Seda Karabulut. Medipol University, School of Medicine, Department of Histology and Embryology, Kavacik mah, Ekinciler cd. No. 19 Beykoz, Istanbul, Turkey. Tel: +90 532 273 98 64. E-mail: sedakarabulut@medipol.edu.tr
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Summary

Intracytoplasmic sperm injection (ICSI) is performed in cases of infertility by injecting a motile and morphologically normal sperm cell under a routine ×400 magnification at which is hard to distinguish morphologically healthy sperm. Recently, the use of high-powered differential interference contrast optics gave the opportunity to select a sperm under ultra-high magnification of ×10,160. The aim of the present study was to evaluate the efficacy of the intracytoplasmic morphologically selected sperm injection (IMSI) technique in different infertility populations undergoing ICSI. Main outcome measures of routine ICSI were compared with IMSI in three different groups of patients (1, non-selected; 2, male infertility; and 3, repeated implantation failure group). Results were analysed to evaluate the effects of the IMSI procedure and to find the most suitable group of patients who may benefit from the procedure. IMSI caused a significant increase in the fertilization and top quality embryo rates in the male infertility group and a significant increase in fertilization and pregnancy rates in the repeated implantation failure group, whereas no effect was observed in the non-selected group with patients of various indications. A positive effect of IMSI on the outcome of male factor infertility and repeated implantation failure patients was observed. Data observed confirmed that the application of IMSI was beneficial for a selected group of patients with male factor infertility and repeated implantation failure.

Keywords

ICSIIMSISpermSperm morphologySperm selection
Type
Research Article
Information
Zygote , Volume 27 , Issue 5 , October 2019 , pp. 299 - 304
Copyright
© Cambridge University Press 2019 

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