Hostname: page-component-8448b6f56d-t5pn6 Total loading time: 0 Render date: 2024-04-19T15:24:13.062Z Has data issue: false hasContentIssue false

Plasma prolactin and luteinizing hormone levels in anorexia nervosa1

Published online by Cambridge University Press:  09 July 2009

P. J. V. Beumont*
Affiliation:
Department of Psychiatry, University of Oxford, and the Royal Victoria Hospital, Montreal, Canada
H. G. Friesen
Affiliation:
Department of Psychiatry, University of Oxford, and the Royal Victoria Hospital, Montreal, Canada
M. G. Gelder
Affiliation:
Department of Psychiatry, University of Oxford, and the Royal Victoria Hospital, Montreal, Canada
T. Kolakowska
Affiliation:
Department of Psychiatry, University of Oxford, and the Royal Victoria Hospital, Montreal, Canada
*
2Address for correspondence: Dr. P. J. V. Beumont, Department of Psychiatry, Groote Schuur Hospital, Cape Town, South Africa.

Sysnopsis

Five emaciated patients suffering from anorexia nervosa were studied. Mean plasma prolactin levels, as measured by radioimmunoassay, were within the normal range, although mean plasma levels of luteinizing hormone were depressed. This association is of interest as it suggests that basal levels of circulating prolactin are not affected by the hypothalamic disorder found in patients with anorexia nervosa.

Type
Preliminary communication
Copyright
Copyright © Cambridge University Press 1974

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

1

This work was supported by the Medical Research Council, Grant G970/227C.

References

REFERENCES

Ben-David, M., Danon, A., and Sulman, F. G. (1971). Evidence of antagonism between prolactin and gonado-trophin secretion: effect of methalibure on perphenazine-induced prolactin secretion in ovariectomized rats. Journal of Endocrinology, 51, 719725.CrossRefGoogle Scholar
Bell, E. T., Harkness, R. A., Loraine, J. A., and Russell, G. F. M. (1966). Hormone assay studies in patients with anorexia nervosa. Acta Endocrinologica(Kbh), 51, 140148.Google ScholarPubMed
Besser, G. M., Parke, L., Edwards, C. R. W., Forsyth, I. A., and McNeilly, A. S. (1972). Galactorrhoea: successful treatment with reduction of plasma prolactin levels by Brom-ergocryptine. British Medical Journal, 3, 669672.CrossRefGoogle ScholarPubMed
Beumont, P. J. V., Beardwood, C. J., and Russell, G. F. M. (1972). The occurrence of the syndrome of anorexia nervosa in male subjects. Psychological Medicine, 2, 216231.CrossRefGoogle ScholarPubMed
Beumont, P. J. V., Carr, P. J., and Gelder, M. G. (1973). Plasma levels of luteinizing hormone and of immunoreac-tive oestrogens in anorexia nervosa: response to clomiphene citrate. Psychological Medicine, 3, 495501.CrossRefGoogle Scholar
Beumont, P. J. V., Harris, G. W., Carr, P. J., Friesen, H. G., Kolakowska, T., MacKinnon, P. C. B., Mandelbrote, B. M., and Wiles, D. (1972). Some endocrine effects of phenothiazines: a preliminary report. Journal of Psychosomatic Research, 16, 297304.CrossRefGoogle ScholarPubMed
Bliss, E. L., and Branch, C. H. H. (1960). Anorexia Nervosa. Hoeber: New York.Google Scholar
Friesen, H., Guyda, H., Hwang, P., Tyson, J. E., and Barbeau, A. (1972). Functional evaluation of prolactin secretion: a guide to therapy. Journal of Clinical Investigation, 51, 706709.CrossRefGoogle ScholarPubMed
Hwang, P., Guyda, H., and Friesen, H. (1971). A radio-immunoassay for human prolactin. Proceedings of the National Academy of Science, 68, 19021906.CrossRefGoogle Scholar
Landon, J., Greenwood, F. C., Stamp, T. C. B., and Wynn, V. (1966). The plasma sugar, free fatty acid, Cortisol, and growth hormone response to insulin, and the comparison of this procedure with other tests of pituitary and adrenal function. 2. In patients with hypolhalamic or pituitary dysfunction or anorexia nervosa. Journal of Clinical Investigation, 45, 437449.CrossRefGoogle ScholarPubMed
Lewin, K., Mattingly, D., and Millis, R. R. (1972). Anorexia nervosa associated with hypothalamic tumour. British Medical Journal, 2, 629630.CrossRefGoogle ScholarPubMed
Marks, V. and Howorth, N., and Greenwood, F. C. (1965). Plasma growth-hormone levels in chronic starvation in man. Nature, 208, 686687.CrossRefGoogle Scholar
Marshall, J. C., and Fraser, T. R. (1971). Amenorrhoea in anorexia nervosa: assessment and treatment with clomiphene citrate. British Medical Journal, 4, 590592.CrossRefGoogle ScholarPubMed
Midgley, A. R. Jr. (1966). Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone. Endocrinology, 79, 1018.CrossRefGoogle ScholarPubMed
Neri, V., Ambrosi, B., Beck-Peccoz, P., Travaglini, P. and Faglia, G. (1972). Growth hormone regulation and hypo-thalamic-pituitary-adrenal function in anorexia nervosa. Folia Endocrinologica, 25, 143152.Google Scholar
Russell, G. F. M. (1970). Anorexia nervosa: its identity as an illness and its treatment. In Modern Trends in Psychological Medicine, 2. pp. 131164. Edited by Price, J. H.. Butter-worths: London.Google Scholar
Society of Actuaries (1959). Build and Blood Pressure Study, Vol. 1. Society of Actuaries: Chicago.Google Scholar
Wakeling, A., and Russell, G. F. M. (1970). Disturbances in the regulation of body temperature in anorexia nervosa. Psychological Medicine, 1, 3039.CrossRefGoogle ScholarPubMed