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Stress, immunity and illness — a review

Published online by Cambridge University Press:  09 July 2009

Barbara Dorian  and
Paul E. Garfinkel
Barbara Dorian
Affiliation:
Department of Psychiatry, Toronto General Hospital, Toronto, Canada
Paul E. Garfinkel*
Affiliation:
Department of Psychiatry, Toronto General Hospital, Toronto, Canada
*
1Address for correspondence: Dr Paul E. Garfinkel, Psychiatrist-in-Chief, Department of Psychiatry, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ont. M5G 2C4. Canada
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Synopsis

Psychological factors have long been thought to play a contributing role in either the predisposition, onset or course of various physical illnesses. Recently, rapid advances in immunology have created interest in the interaction between psychosocial factors, behaviour and the immune system. This paper reviews some of the models proposed to explain the relationship between psychological variables and physical illness and presents evidence for a contribution of psychological factors to certain illnesses in which abnormalities in immunologic state are thought to be important. From a somewhat different perspective, animal studies have demonstrated complex effects of stress, on disease susceptibility. Recent human studies have demonstrated consistent immunologic changes in people undergoing acute naturally occurring psychological stress such as bereavement or an important examination. In humans, the effects of chronic stress may be different from acute stress, corresponding to the findings in animals. Abnormalities in immunologic functioning and physical illness are reviewed for different psychiatric disorders — depression, anorexia nervosa and schizophrenia; depression is the only disorder which consistently demonstrated immunologic changes. Possible mechanisms for the stress/immune-change relationship are suggested.

Type
Research Article
Information
Psychological Medicine , Volume 17 , Issue 2 , May 1987 , pp. 393 - 407
Copyright
Copyright © Cambridge University Press 1987

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References

Abeloff, M. D. & Derogatis, L. R. (1977). Psychologic aspects of the management of primary metastatic breast cancer. Progress of Clinical Biological Research 12, 505–516.Google Scholar
Ackerman, S. H., Hofer, M. A. & Weiner, H. (1979). Sleep and temperature regulation during restraint Stress in rats is affected by prior maternal separation. Psychosomatic Medicine 41, 311–319.CrossRefGoogle ScholarPubMed
Ader, R. & Friedman, S. B. (1965). Differential early experiences and susceptibility to transplanted tumor in the rat. Journal of Comparative Physiology and Psychology 59, 361–364.Google Scholar
Albrecht, P., Torrey, E. F., Boone, E., Hicks, J. T. & Daniel, N. (1980). Raised cytomegalovirus-antibody level in cerebrospinal fluid of schizophrenic patients. Lancet ii, 769–772.Google Scholar
Albrecht, J., Helderman, J. H., Schlesser, M. A. & Rush, A. J. (1985). A controlled study of cellular immune function in affective disorders before and during somatic therapy. Psychiatric Research 15, 185–193.CrossRefGoogle ScholarPubMed
Amkraut, A. A. & Solomon, G. F. (1972). Stress and murine sarcoma virus (Maloney) — induced tumours. Cancer Research 32, 1428–1433.Google Scholar
Amkraut, A. A., Solomon, G. F., & Kraemer, H. C. (1971). Stress, early experience and adjuvant-induced arthritis in the rat. Psychosomatic Medicine 33, 203–214.Google Scholar
Armstrong-Esther, C. A., Lacey, J. H., Crisp, A. H. & Bryant, T. N. (1978). An investigation of the immune response of patients suffering from anorexia nervosa. Postgraduate Medicinal Journal (632) 54, 395–399.Google Scholar
Ashkenazi, A., Krasilowsky, D., Levin, S., Idar, D., Kalian, M., Or, A., Ginat, Y. & Halperin, B. (1979). Immunologic reaction of psychotic patients to fractions of gluten. American Journal of Psychiatry 136, 1306–1309.Google ScholarPubMed
Aulakh, G. S., Kleinman, J. E., Aulakh, H. S., Albrecht, P., Torrey, E. F. & Wyatt, R. J. (1981). Search for cytomegalovirus in schizophrenic brain tissue. Processes in Social, Experimental and Biological Medicine 167, 172–174.Google Scholar
Avery, D. & Winokur, G. (1976). Mortality in depressed patients treated with electroconvulsive therapy and anti-depressants. Archives of General Psychiatry 33, 1029–1037.CrossRefGoogle Scholar
Bahnson, C. B. (1980). Stress and cancer: the state of the art. Psychosomatics 21 (12), 975–981.Google Scholar
Baker, G. A., Sautalo, R., & Blumenstein, J. (1977). Effect of psychotropic agents upon the blastogenetic response of human T-lymphocytes. Biological Psychiatry 12, 159–169.Google Scholar
Baldwin, J. A. (1979). Schizophrenia and physical disease. Psychological Medicine 9, 611–618.CrossRefGoogle ScholarPubMed
Bartrop, R. W., Luckhurst, E., Lazarus, L., Kiloh, L. G. & Penny, R. (1977). Depressed lymphocyte function after bereavement. Lancet, i, 834–836.CrossRefGoogle Scholar
Bergen, J. R., Grinspoon, L. & Pyle, H. M. (1980). Immunologic studies in schizophrenic and control subjects. Biological Psychiatry 15, 369–379.Google Scholar
Berkman, J. M. (1948). Anorexia nervosa, anterior-pituitary insufficiency, Simmonds' cachexia, and Sheehan's disease: including some observations on disturbances in water metabolism associated with starvation. Postgraduate Medicine 3, 237–246.Google Scholar
Blumberg, E. M., West, P. M. & Ellis, F. W. (1954). A possible relationship between psychological factors and human cancer. Psychosomatic Medicine 16, 276–286.CrossRefGoogle ScholarPubMed
Borysenko, J. Z. (1982). Behavioural-physiological factors in the development and management of cancer. General Hospital Psychiatry 4, 69–74.CrossRefGoogle Scholar
Borysenko, M. & Borysenko, J. (1982). Stress, behaviour, and immunity: animal models and mediating mechanisms. General Hospital Psychiatry 4, 59–67.Google Scholar
Bowers, T. K. & Eckert, E. (1978). Leukopenia in anorexia nervosa: lack of increased risk of infection. Archives of Internal Medicine 138, 1520–1523.CrossRefGoogle ScholarPubMed
Caplan, G. (1970). Theory and Practice of Mental Health Consultation. Basic Books: New York.Google Scholar
Cappel, R., Gregoire, F., Thiry, L. & Sprecher, S. (1978). Antibody and cell mediated immunity to herpes simplex virus in psychotic depression. Journal of Clinical Psychiatry 39, 266–268.Google ScholarPubMed
Cassileth, B. R., Lush, E. J. & Miller, D. S., (1985). Psychosocial correlates of survival in advanced malignant disease? New England Journal of Medicine 312, 1551–1555.CrossRefGoogle ScholarPubMed
Certcov, D. (1969). Immunity and mental illness: A study of the immediate and delayed skin response to a series of various antigens. Annals of Medical Psychology 127, 733–742.Google Scholar
Chandra, R. K. (1980). Nutritional deficiency, immune responses, and infectious illness. Symposium at the 64th Annual Meeting of the Federation of American Societies for Experimental Biology, Anaheim, California.Google Scholar
Clayton, P. J. (1979). The sequelae and nonsequelae of conjugal bereavement. American Journal of Psychiatry 136(12), 1530–1534.Google ScholarPubMed
Cohen-Cole, S., Cogen, R., Stevens, A., Kirk, K., Gaitan, E., Hain, J. & Freeman, A. (1981). Psychosocial, endocrine, and immune factors in acute necrotizing ulcerative gingivitis (‘trenchmouth’). Psychosomatic Medicine 43, 91–95.Google Scholar
Crow, T. J., Ferrier, I. N., Johnstone, E. C., MacMillan, J. F., Owens, D. G. C., Parry, R. P. & Tyrell, D. A. (1979). Characteristics of patients with schizophrenia or neurological disorder and virus-like agent in cerebrospinal fluid. Lancet i, 842–844.Google Scholar
Dally, P. (1969). Anorexia Nervosa. Grune and Stratton: New York.Google Scholar
Dattore, P. J., Shontz, F. C., & Coyne, L. (1980). Premorbid personality differentiation of cancer and non-cancer groups: A test of the hypothesis of cancer proneness. Journal of Consultation and Clinical Psychology 48, 388–394.Google Scholar
De Lisi, L. E., Goodman, S., Neckers, L. M. & Wyatt, R. J.(1982). An analysis of lymphocyte subpopulations in schizophrenic patients. Biological Psychiatry 17, 1003–1009.Google ScholarPubMed
Dohan, F. C. & Grasberger, J. C. (1973). Relapsed schizophrenics: Earlier discharge from the hospital after cereal-free, milk-free diet. American Journal of Psychiatry 130, 685–688.CrossRefGoogle ScholarPubMed
Domino, E. F., Krause, R. R. & Theissen, M. M. (1975). Blood protein fraction comparisons of normal and schizophrenic patients. Archives of General Psychiatry 32, 717–721.Google Scholar
Dorian, B. J., Garfinkel, P. E., Keystone, E. C., Gorczynski, R., Garner, D. M., Darby, P. & Shore, A. (1985). Occupational stress and immunity. Psychosomatic Medicine 47, 77.Google Scholar
Dorian, B. J., Garfinkel, P. E., Brown, G., Shore, A., Gladman, D., Keystone, E. C. & Darby, P. (1986). Stress, immunity and illness. Psychosomatic Medicine 48, 304.Google Scholar
Dorian, B. J., Garfinkel, P. E., Brown, G. M., Shore, A., Gladman, D. & Keystone, E. (1982). Aberrations in lymphocyte subpopulations and functions during psychological Stress. Clinical and Experimental Immunology 50, 132–138.Google ScholarPubMed
Edwards, E. A. & Dean, L. M. (1977). Effects of crowding mice on humoral antibody formation and protection to lethal antigenic challenge. Psychosomatic Medicine 39, 19–24.CrossRefGoogle ScholarPubMed
Feigenbaum, S. L., Masi, A. T. & Kaplan, S. B. (1979). Prognosis in rhematoid arthritis: a longitudinal study of newly diagnosed younger adult patients. American Journal of Medicine 66, 377–384.Google Scholar
Fischer, E. G. & Falke, N. E. (1984). β-endorphin modulates immune functions. Psychotherapy Psychosomatics 42, 195–204.CrossRefGoogle ScholarPubMed
Fontana, A., Storck, U., Angst, J., Dubs, R., Abegg, A. & Grob, P. J. (1980). An immunological basis of schizophrenia and affective disorders. Neuropsychobiology 6, 284–289.CrossRefGoogle ScholarPubMed
Fox, B. H. (1981). Psychosocial factors in the immune system in human cancer. In Psychoneuroimmunology. (Ed. Ader, R.), pp. 103–158. Academic Press: New York.Google Scholar
Friedman, S. B., Cohen, J. & Iker, H. (1967). Antibody response to cholera vaccine: differences between depressed, schizophrenic and normal subjects. Archives of General Psychiatry 16, 312–315.CrossRefGoogle ScholarPubMed
Fundenberg, H. H. (1968). Are autoimmune diseases immunologic deficiency states? Hospital Practice 3, 43–53.CrossRefGoogle Scholar
Gisler, R. H., Bussard, A E., Mazie, J. C. & Hesse, R. (1971). Hormonal regulation of the immune response: I. Induction of an immune response in vitro with lymphoid cells from mice exposed to acute systemic stress. Cell Immunology 2, 634–645.CrossRefGoogle ScholarPubMed
Glaser, R., Kiecolt-Glaser, J. K., Speicher, C. E. & Holliday, J. E. (1985 a). Stress, loneliness, and changes in herpes virus latency. Journal Behavioural Medicine 8, 249–260.Google Scholar
Glaser, R., Kiecolt-Glaser, J. K., Stout, J. C., Tarr, K. L., Speicher, C. E. & Holliday, J. E. (1985 b). Stress-related impairment in cellular immunity. Psychiatry Research 16, 233–239.Google Scholar
Glaser, R., Rice, J., Sheridan, J., Post, A., Fertel, R., Stout, J., Speicher, C. E., Kotur, M. & Kiecolt-Glaser, J. K. (1987). Stress-related immune suppression: Health implications.CrossRefGoogle Scholar
Goldmeier, D. & Johnson, D. (1982). Does psychiatric illness affect the recurrence rate of genital herpes? British Journal of Venereal Disease 58, 40–43.Google ScholarPubMed
Golla, J. A., Larson, L. A., Anderson, C. F., Lucas, A. R., Wilson, W. R. & Tomasi, T. B. (Jr). (1981). An immunological assessment of patients with anorexia nervosa. American Journal of Clinical Nutrition 34, 2756–2762.Google Scholar
Gotch, F. M., Spry, C. J. F., Mowat, A. G., Beeson, P. B. & MacLennon, I. C. M. (1975). Reversible granulocyte killing defect in anorexia nervosa. Clinical Experimental Immunology 21, 244–249.Google Scholar
Greene, W. H. (1966). The psychosocial setting of the development of leukemia and lymphoma. Annals of New York Academy of Science 125, 794–801.Google Scholar
Greer, S. (1983). Cancer and the mind. British Journal of Psychiatry 143, 535–543.Google Scholar
Greer, S. & Morris, T. (1975). Psychological attributes of women who develop breast cancer: a controlled study. Journal of Psychosomatic Research 19, 147–153.CrossRefGoogle ScholarPubMed
Grossarth-Maticek, R., Bastiaans, J. & Kanazin, DT. (1985). Psychosocial factors as strong predictors of mortality from cancer, ischaemic heart disease and stress: the Yugoslav Prospective Study. Journal of Psychosomatic Research 29, 167–176.Google Scholar
Hall, N. R. & Goldstein, A. L. (1981). Neurotransmitter and the immune system, In Psychoneuroimmunology (ed. Ader, R.), pp. 521–538. Academic Press: New York.Google Scholar
Hamilton, D. R. (1974). Immunosuppressive effects of predator induced stress in mice with acquired immunity to hyrnenolepis nana. Journal of Psychosomatic Research 18, 143–153.CrossRefGoogle ScholarPubMed
Heath, R. G., Krupp, I. M., Byers, L. W. & Liljekvist, J. I. (1967). Schizophrenia as an immunological disorder: III. Effect of anti-monkey and anti-human brain antibody on brain function. Archives of General Psychiatry 16, 24–33.CrossRefGoogle Scholar
Heath, R. G., Fitzjarrel, A. & Krupp, I. M. (1968). Schizophrenic gamma G immunoglobulin at specific brain sites. Abstract.Scientific Proceedings, 124th Annual Meeting American Psychiatric Association:Washington, D.C.Google Scholar
Helsing, K. J. & Szklo, M. (1981). Mortality after bereavement. American Journal of Epidemiology 114, 41–52.CrossRefGoogle ScholarPubMed
Henney, C. S., Bourne, H. R. & Lichtenstein, L. M. (1972). The role of cyclic 3'-5' adenosine monophosphate in the specific cytolytic activity of lymphocytes. Journal of Immunology 108, 1526–1534.CrossRefGoogle Scholar
Holmes, T. & Rahe, R. (1967). The social readjustment rating scale. Journal of Psychosomatic Research 11, 213–218.Google Scholar
Horne, K. Z. & Picard, R. S. (1979). Psychosocial risk actors for lung cancer. Psychosomatic Medicine 41(7), 503–514.Google Scholar
Jacobs, S. & Ostfeld, A. (1977). An epidemiological review of the mortality of bereavement. Psychosomatic Medicine 39, 344–357.Google Scholar
Jansen, M. A. & Muenz, L. R. (1983). A retrospective study of personality variables associated with fibrocystic disease and breast cancer.Google Scholar
Jemmott, J. B. III, Borysenko, J. Z., Borysenko, M., McClelland, D. C., Chapman, R., Meyer, D. J. & Benson, H. (1983). Academic stress, power motivation, and decrease in secretion rate of salivary secretory immunoglobulin A. Lancet 1, 1400–1402.Google Scholar
Joasoo, A. & McKenzie, J. M. (1976). Stress and the immune response in rats. International Archives of Allergy and Applied Immunology 50, 659–663.CrossRefGoogle ScholarPubMed
Justice, A. (1985). Review of the effects of stress on cancer in laboratory animals: importance of time of stress application and type of tumour. Psychological Bulletin 98, 108–138.CrossRefGoogle Scholar
Kasl, S. V., Evans, A. S. & Weidermann, J. C. (1979). Psychosocial risk factors in the development of infectious mononucleosis. Psychosomatic Medicine 41, 445–466.Google Scholar
Keller, S. E., Weiss, J. M., Schleifer, S. J., Miller, N. E. & Stein, M. (1981). Suppression of immunity by stress: effect of a graded series of stressors on lymphocyte stimulation in the rat. Science 213, 1397–1400.Google Scholar
Keller, S. E., Ackerman, S. H., Schleifer, S. J., Schindledecker, R. D., Camerino, M. S., Hofer, M. A., Weiner, H. & Stein, M. (1983). Effect of premature weaning on lymphocyte stimulation in the rat. Psychosomatic Medicine 45, 75.Google Scholar
Kiecolt-Glaser, J. K., Speicher, C. E., Holliday, J. E. & Glaser, R. (1984). Stress and the transformation of lymphocytes by Epstein-Barr virus. Journal of Behavioural Medicine 7, 1–12.Google Scholar
Kiecolt-Glaser, J. K., Stephens, R. E., Lipetz, P. D., Speicher, C. E. & Glaser, R. (1985). Distress and DNA repair in human lymphocytes. Journal of Behavioural Medicine 8, 311–320.Google Scholar
Kiecolt-Glaser, J. K., Fisher, L., Ogrocki, P., Stout, J. C., Speicher, C. E. & Glaser, R. (1987). Marital quality, marital disruption, and immune function, Psychosomatic Medicine (in the press).Google Scholar
Kim, Y. & Michael, A. F. (1975). Hypocomplementemia in anorexia nervosa. Journal of Pediatrics 87, 582–585.CrossRefGoogle ScholarPubMed
Kimzey, S. L., Johnson, P. C., Ritzman, S. E. & Mengel, C. E. (1976). Hematology and immunology studies: The second manned Skylab mission. Aviation, Space, and Environmental Medicine 47, 383–390.Google Scholar
Kissen, D M. (1963). Personality characteristics in males conducive to lung cancer. British Journal of Medical Psychology 36, 27–36.Google Scholar
Kissen, D. M. (1967). Psychosocial factors, personality and lung cancer in men aged 55–64. British Journal of Medical Psychology 40, 29–43.CrossRefGoogle Scholar
Klerman, G. L. & Izen, J. E. (1977). The effects of bereavement and grief on physical health and general well-being. Advances in Psychosomatic Medicine 9, 63–104.Google Scholar
Kovaleva, E. S., Bonartsev, P. D. & Prilipko, L. L. (1978). Response of lymphocytes of patients with schizophrenia to phytomitogens concavalin A and phytohaemagglutinin. Bulletin of Experimental Biological Medicine 84, 1136–1139.CrossRefGoogle Scholar
Krasnoff, A. (1959). Psychological variables and human cancer: a cross validation study. Psychosomatic Medicine 21, 291–295.Google Scholar
Kronfol, Z., Silva, J. Jnr, Greden, J., Dembinski, S., Gardner, R. & Carroll, B. (1983). Impaired lymphocyte function in depressive illness. Life Sciences 33, 241–247.Google Scholar
La Barba, R. C. (1970). Experimental and environmental factors in cancer: a review of research with animals. Psychosomatic Medicine 32, 259–276.CrossRefGoogle Scholar
Laudenslager, M., Capitano, J P. & Reite, M. (1985). Possible effects of early separation experiences on subsequent immune function in adult macaque monkeys. American Journal of Psychiatry 142 (7), 862–864.Google ScholarPubMed
Le Shan, L. L. (1966). An emotional life history pattern associated with neoplastic disease. Annals of the New York Academy of Science 125, 780–793.Google Scholar
Linn, B. S., Linn, M. W. & Jensen, J. (1982). Degree of depression and immune responsiveness. Psychosomatic Medicine 44, 128–129.Google Scholar
Locke, S. E. (1982). Stress, adaptation, and immunity: Studies in humans. General Hospital Psychiatry 4, 49–58.CrossRefGoogle ScholarPubMed
Locke, S. E., Kraus, L., Leserman, J. M., Hurst, M. W., Heisel, S. & Williams, R. M. (1984). Life change stress, psychiatric symptoms, and natural killer cell activity. Psychosomatic Medicine 45, 441–453.CrossRefGoogle Scholar
Luborsky, L., Mintz, J., Brightman, V. J. & Katcher, A. H. (1976). Herpes simplex virus and moods: a longitudinal study. Journal of Psychosomatic Research 20, 543–548.Google Scholar
Lycke, E., Norrby, R. & Roos, B. (1974). A serological study on mentally ill patients. British Journal of Psychiatry 124, 273–279.CrossRefGoogle Scholar
McClelland, D. C., Floor, E., Davidson, R. J. & Saron, C., (1980). Stressed power motivation, sympathetic activation, immune function, and illness. Journal of Human Stress 6, 11–19.Google Scholar
McClelland, D. C., Alexander, C. & Marks, E. (1982). The need for power, stress, immune function, and illness among male prisoners. Journal of Abnormal Psychology 91, 61–70.CrossRefGoogle ScholarPubMed
McCoy, J. W. (1978). Psychological variables and onset of cancer. Dissertation Abstracts International 38, 4471.Google Scholar
Mastrovito, R. C., Deguire, K. S., Clarkin, J., Thaler, T., Lewis, J. L. & Cooper, E. (1979). Personality characteristics of women with gynecological cancer. Cancer Detection and Prevention 2, 281–287.Google Scholar
Meyerowitz, S., Jacox, R. F. & Hess, D. W. (1968). Monozygotic twins discordant for rheumatoid arthritis: a genetic, clinical and psychological study of 8 sets. Arthritis and Rheumatology 11, 1–21.Google Scholar
Moldofsky, H. & Chester, W. J. (1970). Pain and mood patterns in patients with rheumatoid arthritis: a prospective study. Psychosomatic Medicine 32, 309–318.Google Scholar
Moos, R. H. & Solomon, G. F. (1964). Minnesota multiphasic personality inventory response patterns in patients with rheumatoid arthritis. Journal of Psychosomatic Research 8, 17–28.Google Scholar
Newberry, B. H. (1978). Restraint-induced inhibition of 7·12 dimethylbenz(a) anthracene-induced mammary tumors: relation to stages of tumor development Journal of the National Cancer Institute 61, 725–729.Google Scholar
Newberry, B. H., Frankie, G., Beatty, P. A., Maloney, B. D. & Gilchrist, J. C. (1972). Shock stress and DMBA-induced mammary tumors. Psychosomatic Medicine 34, 295–303.Google Scholar
Newberry, B. H., Gildow, J., Wogan, J. & Reese, K. L. (1976). Inhibition of Huggins tumors by forced restraint. Psychosomatic Medicine 38, 155–162.Google Scholar
Niemi, T. & Jaakelainen, J. (1978). Cancer morbidity in depressive persons. Journal of Psychosomatic Research 22, 117–120.Google Scholar
Palmblad, J. (1981). Stress and immunologic competence: studies in man. In Psychoneuroimmunology. (ed. Ader, R.), pp. 229–258. Academic Press: New York.Google Scholar
Palmblad, J., Blomback, M., Egberg, N., Froberg, J., Karlsson, C. & Levi, L. (1977). Experimentally induced stress in man: effects on blood coagulation and fibrinolysis. Journal of Psychosomatic Research 21, 87–92.CrossRefGoogle ScholarPubMed
Parkes, C. M. (1985). Bereavement. British Journal of Psychiatry 146, 11–17.Google Scholar
Peters, L. J. (1975). Enhancement of syngeneic murine tumour transplantation by whole body irradiation – a nonimmunological phenomenon. British Journal of Cancer 31, 293–300.Google Scholar
Peters, L. J. & Kelly, H. (1977). The influence of stress hormones on the transplantability of a non-immunogenic syngeneic murine tumour. Cancer 39, 1482–1488.Google Scholar
Peterson, M. R., Brannon, W. L., Carpenter, W. T., Post, R. M. & Van Kammen, D. P. (1978). Immunoglobulins and viral antibodies in psychiatric patients. British Journal of Psychiatry 132, 341–348.Google Scholar
Pettingale, K. W., Greer, S. & Tee, D. E. H. (1977). Serum IgA and emotional expression in breast cancer patients. Journal of Psychosomatic Research 21, 395–399.CrossRefGoogle ScholarPubMed
Plotnikoff, N. P., Miller, G. C. & Murgo, A. J. (1982). Enkephalinsendorphins: immunomodulators in mice. International Journal of Immunopharmacology 4, 366–367.Google Scholar
Pradhan, S. N. & Ray, P. (1974). Effects of stress on growth of transplanted and 7 12 dimethylbenz(a) anthracene-induced tumors and their modification by psychotropic drugs. Journal of the National Cancer Institute 53, 1241–1245.CrossRefGoogle Scholar
Pulkkinen, E. (1977). Immunoglobulins, psychopathology and prognoses in schizophrenia. Acta Psychiatrica Scandinavia 56, 172–182.CrossRefGoogle ScholarPubMed
Rauscher, F. P., Nasrallah, H. A. & Wyatt, R. J. (1980). Cutaneous histamine response in schizophrenia. Journal of Clinical Psychology 41, 44–51.Google Scholar
Rees, W. L. (1976). Stress, distress and disease. British Journal of Psychiatry 128, 3–18.CrossRefGoogle ScholarPubMed
Reite, M., Harbeck, R. & Hoffman, A. (1981). Altered cellular immune response following peer separation. Life Science 29, 1133–1135.CrossRefGoogle ScholarPubMed
Rimon, R., Halonen, P., Anttinen, E. & Evola, E. (1971). Complement fixing antibody to herpes simplex virus in patients with psychotic depression. Diseases of the Nervous System 32, 822–824.Google ScholarPubMed
Rogentine, G. N. Jr, van Kammen, D. P., Fox, B H., Docherty, J. P., Rosenblatt, J. E., Boyd, S. C. & Bunney, W. E. Jr (1979). Psychological factors in the prognosis of malignant melanoma: a prospective study. Psychosomatic Medicine 41, 647–655.CrossRefGoogle ScholarPubMed
Rogers, M. P., Dubey, M. D. & Reich, P. (1979). The influence of the psyche and the brain on immunity and disease susceptibility: a critical review. Psychosomatic Medicine 41, 147–164.CrossRefGoogle ScholarPubMed
Rogers, M. P., Trentham, D. E., McCune, W. J., Ginsberg, B. I., Rennke, H. G., Reike, P. & David, J R. (1980). Effect of psychological stress on the induction of arthritis in rats. Arthritis and Rheumatology 23(12), 1337–1342.CrossRefGoogle ScholarPubMed
Roos, R. P., Davis, K. & Meltzer, H. Y. (1985). Immunoglobulin studies in patients with psychiatric disease. Archives of General Psychiatry 42, 124–128.Google Scholar
Saba, T. M. & Antikatzides, T. G. (1976). Decreased resistance to intravenous tumour cell challenge during reticuloendothelial depression following surgery. British Journal of Cancer 34, 281–389.CrossRefGoogle ScholarPubMed
Sachar, E. J. (1975). Neroendocrine abnormalities in depressive illness. In Topics in Psychoendocrinology. (ed. Sachar, E. J.), pp. 135–156. Grune and Stratton: New York.Google Scholar
Scherg, H., Cramer, I. & Blohmke, M. (1981). Psychosocial factors and breast cancer: a critical re-evaluation of established hypotheses. Cancer Detection and Prevention 4, 165–171.Google Scholar
Schleifer, S. J., Keller, S. E., Camerino, M., Thornton, J. C. & Stein, M. (1983). Suppression of lymphocyte stimulation following bereavement. Journal of the American Medical Association 250, 374–377.Google Scholar
Schleifer, S., Keller, S., Meyerson, A., Raskin, M. J., Davis, K. L. & Stein, M. (1984). Lymphocyte function in major depressive disorder. Archives of General Psychiatry 41, 484–486.CrossRefGoogle ScholarPubMed
Schleifer, S. J., Keller, S. E., Siris, S. G., Davis, K. L. & Stein, M. (1985). Depression and immunity. Lymphocyte function in ambulatory depressed patients, hospitalized schizophrenic patients, and patients hospitalized for herniorrhaphy. Archives of General Psychiatry 42, 129–133.CrossRefGoogle ScholarPubMed
Schmale, A. H. Jr & Iker, H. P. (1966). The psychological setting of uterine cervical cancer. Annals of the New York Academy of Science 125, 807–813.CrossRefGoogle ScholarPubMed
Selvini Palazzoli, M. D. (1970). Anorexia nervosa. In The World Biennial of Psychiatry and Psychotherapy, Volume I. (ed. Arieti, S.), pp. 197–218. Basic Books: New York.Google Scholar
Sengar, D. P. S., Waters, B. G. H., Dunne, J. V. & Bouer, I. M. (1982). Lymphocyte subpopulations and mitogenic responses of lymphocytes in manic-depressive disorders. Biological Psychiatry 17(9), 1017–1022.Google Scholar
Shekelle, R. B., Raynor, W. J., Ostfeld, A. M., Garron, D. C., Bieliauskas, L. A., Liv, S.C., Maliza, C. & Paul, O. (1981). Psychological depression and 17 year risk of death from cancer. Psychosomatic Medicine 43, 117–125.CrossRefGoogle ScholarPubMed
Shrikande, S., Hirsch, S. R., Coleman, J. C., Reveley, M. A. & Dayton, R. (1985). Cytomegalovirus and schizophrenia: a test of a viral hypothesis. British Journal of Psychiatry 146, 503–506.Google Scholar
Singh, M. M. & Kay, S. R. (1976). Wheat gluten as a pathogenic factor in schizophrenia. Science 191, 401–402.Google Scholar
Sklar, L. S. & Anisman, H. (1979). Stress and coping factors influence tumour growth. Science 205, 513–515.Google Scholar
Solomon, G. F. (1981). Emotional and personality factors in the onset and course of autoimmune disease, particularly rheumatoid arthritis. In Psychoneuroimmunology (ed. by Ader, R.), pp. 259–280. Academic Press: New York.Google Scholar
Solomon, G. F. & Amkraut, A. A. (1981). Psychologic and central nervous system influences on immune mechanisms. Annual Review of Microbiology 35, 155–184.Google Scholar
Solomon, G. F., Amkraut, A. A. & Kasper, P. (1969). Immunity, emotions and stress. Annals of the New York Academy of Science 164, 335–343.CrossRefGoogle Scholar
Solomon, G. F., Amkraut, A. A. & Rubin, R. T. (1979). Stress and psychoimmunological responses. Presented Canadian Psychiatric Association, Vancouver, British Colombia.Google Scholar
Stan, T. B., Lundin, A. P. & Carpenter, C. B. (1980). The role cyclic nucleotides in lymphocyte activation and function. Progress in Clinical Immunology 3, 115–153.Google Scholar
Stein, M., Keller, S. & Schliefer, S. (1981). The hypothalamus and the immune response. In Brain, Behaviour and Bodily Disease. (ed. Weiner, H., Hofer, M. &Stunkard, A. J.), pp. 45–65. Raven Press: New York.Google Scholar
Stavraky, K. M., Buck, C. N., Lott, J. S. & Worklin, J. M. (1968). Psychological factors in the outcome of human cancer. Journal of Psychosomatic Research 12, 251–259.Google Scholar
Stevens, J. R., Langloss, J. M., Albrecht, P., Yolken, R. & Wang, Y. N. (1984). A search cytomegalovirus and herpes viral antigen in brains of schizophrenic patients. Archives of General Psychiatry 41, 795–801.Google Scholar
Stroebe, M. S., Stroebe, W., Gergen, K. J. & Gergen, M. (1982). The broken heart: reality or myth? Omega 12(2), 87–106.Google Scholar
Thomas, C. B., Duszynski, K. R. & Shaffer, J. W. (1979). Family attitudes reported in youth as potential predictors of cancer. Psychosomatic Medicine 41, 287–301.CrossRefGoogle ScholarPubMed
Thomas, P. D., Goodwin, J. M. & Goodwin, J. S (1985). Effect of social support on stress-related changes in cholesterol level, uric acid level, and immune function in an elderly sample. American Journal of Psychiatry 142(6), 735–737.Google Scholar
Totman, R., Kiff, J., Reed, S. E. & Craig, J. W. (1980). Predicting experimental colds in volunteers from different measures of recent life stress. Journal of Psychosomatic Research 24, 155–163.CrossRefGoogle ScholarPubMed
Vartanian, M. E., Kolyaskina, G. I., Lozovsky, D. V., Burbaeva, G. S. & Ignator, S. A. (1978). Aspects of hunioral and cellular immunity in schizophrenia. In Neurochemical and Immunologic Components in Schizophrenia. (ed. Bergman, D. and Goldstein, A. L.), pp. 339–364. Alan R Liss Inc: New York.Google Scholar
Watson, C. G. & Schuld, D. (1977). Psychosomatic factors in the etiology of neoplasms. Journal of Consulting Clinical Psychology 45, 455–461.Google Scholar
Weisman, A. D. & Worden, J. W. (1977). Coping and vulnerability in cancer patients. Monograph of Massachusetts General Hospital and Harvard Medical School, Project Omega II.Google Scholar
Whitlock, F. A. & Siskind, M. (1979). Depression and cancer: a follow up study. Psycholological Medicine 9, 747–752.CrossRefGoogle ScholarPubMed
Wirsching, M., Stierlin, H., Hoffman, F., Weber, G. & Wirsching, B. (1982). Psychological identification of breast cancer patients before biopsy. Journal of Psychosomatic Research 26, 1–10.Google Scholar
Young, M., Bernard, B. & Wallis, G. (1963). The mortality of widowers. Lancet ii, 454–456.Google Scholar