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Chest pain with normal coronary arteries: a comparative study of psychiatric and social morbidity

Published online by Cambridge University Press:  09 July 2009

Christopher Bass*
Affiliation:
King's College Hospital, London
Clyde Wade
Affiliation:
King's College Hospital, London
*
1 Address for correspondence: Dr Christopher Bass Academic Department of Psychological Medicine, King's College Hospital, Denmark Hill, London SE5 9RS.

Synopsis

Ninety-nine patients with chest pain and a presumptive diagnosis of coronary heart disease were assessed blindly within 24 hours of angiography, using standardized psychiatric and social interviews and a personality inventory. Thirty-one patients had normal coronary arteries (NCA), 15 had slight disease and 53 had significant coronary obstruction. Twenty-eight (61%) of the 46 patients with insignificant disease and 12 (23%) of the 53 with significant obstruction had psychiatric morbidity.

Associations between the overall severity of psychiatric morbidity and measures of social maladjustment were strongest in the patients with normal coronary arteries. The 26 men with insignificant coronary artery disease had higher scores of neuroticism and extraversion than the 41 with important coronary occlusions. No differences were observed when the same comparisons were made for the women.

The findings indicate that approximately two thirds of patients with normal and near-normal coronary arteries have predominantly psychiatric rather than cardiac disorders: the symptoms in these patients are more likely to represent the somatic manifestations of anxiety and overbreathing than the consequences of underlying cardiac disease. Physicians should be aware of the ways in which neurotic illness may present with symptoms mimicking cardiac disease, especially when cardiovascular symptoms are accompanied by phobic symptoms and unexplained shortness of breath.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1984

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References

Abrams, H. L. & Adams, D. F. (1969). The coronary anteriogram. New England Journal of Medicine 281, 12761285, 1336–1342.CrossRefGoogle Scholar
Alban, Davies H., Jones, D. B. & Rhodes, J. (1982). ‘Esophageal angina’ as the cause of chest pain. Journal of the American Medical Association 248, 22742278.Google Scholar
Bass, C., Cawley, R., Wade, C., Jackson, G., Gardner, W. N., Hutchison, D. C. S. & Ryan, K. C. (1983). Unexplained breathlessness and psychiatric morbidity in patients with normal and abnormal coronary arteries. Lancet i, 605609.CrossRefGoogle Scholar
Bond, M. R. (1971). The relation of pain to the Eysenck Personality Inventory, Cornell Medical Index and Whitley Index of Hypochon-driasis. British Journal of Psychiatry 119, 671678.CrossRefGoogle Scholar
Bruschke, A. V., Proudfit, W. L. & Sones, F. M. (1973). Clinical course of patients with normal and slightly or moderately abnormal coronary arteriograms. A follow-up study of 500 patients. Circulation 47, 936945.CrossRefGoogle ScholarPubMed
Caston, J., Cooper, L. & Paley, H. W. (1970). Psychological comparison of patients with cardiac neurotic chest pain and angina pectoris. Psychosomatics 11, 543550.CrossRefGoogle ScholarPubMed
Clare, A. W. & Cairns, V. E. (1978). Design, development and use of a standardized interview to assess social maladjustment and dysfunction in community studies. Psychological Medicine 8, 589604.CrossRefGoogle ScholarPubMed
Cohen, M. E. & White, P. D. (1951). Life situations, emotions and neurocirculatory asthenia (anxiety neurosis, neurasthenia, effort syndrome). Psychosomatic Medicine 13, 335357.CrossRefGoogle ScholarPubMed
Cooper, B. (1972). Clinical and social aspects of chronic neurosis. Proceedings of the Royal Society of Medicine 65, 509512.CrossRefGoogle ScholarPubMed
Da, Costa J. M. (1871). On irritable heart; a clinical study of a form of functional cardiac disorder and its consequences. American Journal of the Medical Sciences 61, 1752.Google Scholar
Davies, B. (1964). Psychiatric illness at general hospital clinics. Postgraduate Medical Journal 40, 1518.CrossRefGoogle ScholarPubMed
Day, L. J. & Sowton, E. (1976). Clinical features and follow-up of patients with angina and normal coronary arteries. Lancet ii, 334337.CrossRefGoogle Scholar
Eysenck, H. J. & Eysenck, S. B. (1975). Manual of the Eysenck Personality Questionnaire. Hodder and Stoughton Educational: London.Google Scholar
Eysenck, S. B. (1961). Personality and pain assessment in childbirth of married and unmarried mothers. Journal of Mental Science 107, 417430.CrossRefGoogle ScholarPubMed
Garssen, B., van Weenendaal, W. & Bloemink, R. (1984). Agoraphobia and the hyperventilation syndrome. Behaviour Research and Therapy. (In the press.)Google Scholar
Goldberg, D. P. (1970). A psychiatric study of patients with diseases of the small intestine. Gut 11, 459465.CrossRefGoogle ScholarPubMed
Goldberg, D. P., Cooper, B., Eastwood, M. R., Kedward, H. B. & Shepherd, M. (1970). A standardised psychiatric interview for use in community surveys. British Journal of Preventive and Social Medicine 24, 1823.Google ScholarPubMed
Isner, J. M., Salem, D. N., Banas, J. S. & Levine, H. J. (1981). Long-term clinical course of patients with normal coronary arteriography: follow-up study of 121 patients with normal or near-normal coronary arteriograms. American Heart Journal 102, 645653.CrossRefGoogle ScholarPubMed
Judkins, M. P. (1967). Selective coronary arteriography: I. A percutaneous transfemoral technic. Radiology 89, 815824.CrossRefGoogle Scholar
Kemp, H. G., Elliot, W. C. & Gorlin, R. (1967). The anginal syndrome with normal coronary arteriography. Transactions of the Association of American Physicians 80, 5970.Google ScholarPubMed
Kemp, H. G., Vokonas, P. S., Cohn, P. F. & Gorlin, R. (1973). The anginal syndrome associated with normal coronary arteriograms. Report of a six year experience. American Journal of Medicine 54, 735742.CrossRefGoogle ScholarPubMed
Lancet (1979). Psychiatric illness among medical patients; i, 478479.Google Scholar
Lancet (1980). Chest pain with normal coronary arteries; i, 130.Google Scholar
Lavey, E. B. & Winkle, R. A. (1979). Continuing disability of patients with chest pain and normal coronary arteriograms. Journal of Chronic Disease 32, 191196.CrossRefGoogle ScholarPubMed
Lewis, T. (1918). The Soldiers Heart and the Effort Syndrome. Shaw and Sons: London.Google Scholar
Likoff, W., Segal, B. L. & Kasparian, H. (1967). Paradox of normal selective coronary arteriograms in patients considered to have unmistakeable coronary heart disease. New England Journal of Medicine 276, 10631066.CrossRefGoogle Scholar
Lipowski, Z. J. (1980). Cardiovascular disorders. In Comprehensive Textbook of Psychiatry (ed. Kaplan, H. I., Freedman, A. M. and Sadock, B. J.), pp. 18911907. Williams and Wilkins: Baltimore.Google Scholar
Macdonald, A. J. & Bouchier, I. A. D. (1980). Non-organic gastrointestinal illness: a medical and psychiatric study. British Journal of Psychiatry 136, 276283.CrossRefGoogle ScholarPubMed
Marks, I. & Lader, M. (1973). Anxiety states (anxiety neurosis): a review. Journal of Nervous and Mental Disease 156, 318.CrossRefGoogle ScholarPubMed
Master, A. M. (1964). The spectrum of anginal and non-cardiac chest pain. Journal of the American Medical Association 187, 894899.Google Scholar
Mayou, R. (1973). The patient with angina: symptoms and disability. Postgraduate Medical Journal 49, 250254.CrossRefGoogle ScholarPubMed
Ockene, I. S., Shay, M. J., Alpert, J. S., Weiner, B. H. & Dalen, J. E. (1980). Unexplained chest pain in patients with normal coronary arteriograms. A follow-up study of functional status. New England Journal of Medicine 303, 12491252.CrossRefGoogle ScholarPubMed
Oppenheimer, B. S. & Rothschild, M. A. (1918). The psychoneurotic factor in the ‘irritable heart of soldiers’. British Medical Journal ii, 2931.CrossRefGoogle Scholar
Osler, W. (1892). The Principles and Practice of Medicine. J. Pentland Young: Edinburgh.Google Scholar
Selzer, A. (1977). Cardiac ischaemic pain in patients with normal coronary arteriograms. American Journal of Medicine 63, 661665.CrossRefGoogle ScholarPubMed
Skerritt, P. W. (1983). Anxiety and the heart–a historical review. Psychological Medicine 13, 1725.CrossRefGoogle ScholarPubMed
Waxler, E. B., Kimbiris, D. & Dreifus, L. S. (1971). The fate of women with normal coronary arteriograms and chest pain resembling angina pectoris. American Journal of Cardiology 28, 2532.CrossRefGoogle ScholarPubMed
Wittkower, E., Rodger, T. F. & Macbeth Wilson, A. T. (1941). Effort syndrome. Lancet i, 531535.CrossRefGoogle Scholar
Wood, P. (1941). Da Costa's syndrome (or effort syndrome). British Medical Journal i, 767772, 805–811, 845–851.CrossRefGoogle Scholar
Wooley, C. F. (1976). Where are the diseases of yesteryear? Circulation 53, 749751.CrossRefGoogle ScholarPubMed
World Health Organization (1978). Mental Disorders: Glossary and Guide to their Classification in Accordance with the Ninth Revision of the International Classification of Disease. WHO: Geneva.Google Scholar