Hostname: page-component-8448b6f56d-m8qmq Total loading time: 0 Render date: 2024-04-24T04:11:02.228Z Has data issue: false hasContentIssue false
  • English
  • Français

Stability of the synaptic structure in the hippocampus of BALB/c mice with allergic rhinitis

Published online by Cambridge University Press:  23 February 2015

K Kubo ,
S Jinno ,
K Nariyama  and
S Komune
K Kubo*
Affiliation:
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
S Jinno
Affiliation:
Department of Anatomy and Neurobiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
K Nariyama
Affiliation:
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
S Komune
Affiliation:
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
*
Address for correspondence: Kazuhiko Kubo, Department of Otorhinolaryngology, Kyushu University Hospital, Fukuoka 812-8582, Japan Fax: +81 92 642 5685 E-mail: kubokazu@qent.med.kyushu-u.ac.jp
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

The aim of this study was to determine whether allergic rhinitis can induce structural changes in the synapse formation in the hippocampus of BALB/c mice immunocytochemically.

Methods:

Allergic rhinitis was induced in mice by two intra-peritoneal injections of ovalbumin administered with a one-week interval. After two weeks, the sensitised mice were challenged with an intra-nasal injection of ovalbumin for two weeks. To analyse the hippocampal synaptic structures, sections were immunostained with antibodies against glutamic acid decarboxylase 65 and glutamic acid decarboxylase 67 (for γ-aminobutyric acid-ergic terminals), synaptophysin (for glutamatergic and γ-aminobutyric acid-ergic terminals) and spinophilin (for dendritic spines). The number of nasal rubbing movements was significantly greater in the allergic rhinitis mice than in the control mice. However, the expression patterns of the four above-mentioned synaptic markers in the hippocampus showed no detectable difference between the allergic rhinitis and control mice.

Results and Conclusion:

These data indicate that the synaptic structure in the hippocampus might remain unaltered in allergic rhinitis patients.

Keywords

SpineHippocampusAllergic RhinitisImmunohistochemistry
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue S2 , March 2015 , pp. S56 - S61
Copyright
Copyright © JLO (1984) Limited 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Meltzer, EO. Quality of life in adults and children with allergic rhinitis. J Allergy Clin Immunol 2001;108:S45–53Google Scholar
2Simons, FE. Learning impairment and allergic rhinitis. Allergy Asthma Proc 1996;17:185–9CrossRefGoogle ScholarPubMed
3Scadding, GK. Clinical assessment of antihistamines in rhinitis. Clin Exp Allergy 1999;29:77–81CrossRefGoogle ScholarPubMed
4Tsujii, T, Yamamoto, E, Ohira, T, Takahashi, T, Watanabe, S. Antihistamine effects on prefrontal cortex activity during working memory process in preschool children: a near-infrared spectroscopy (NIRS) study. Neurosci Res 2010;67:80–5CrossRefGoogle ScholarPubMed
5O'Keefe, J. Hippocampus, theta and spatial memory. Curr Opin Neurobiol 1993;3:917–24CrossRefGoogle ScholarPubMed
6von Bohlen, OH. Structure and function of dendritic spines within the hippocampus. Ann Anat 2009;191:518–31CrossRefGoogle Scholar
7Yang, G, Pan, F, Gan, WB. Stably maintained dendritic spines are associated with lifelong memories. Nature 2009;462:920–5Google Scholar
8Sugimoto, Y, Kawamoto, E, Chen, Z, Kamei, C. A new model of allergic rhinitis in rats by topical sensitization and evaluation of H1–receptor antagonists. Immunopharmacology 2000;48:1–7Google Scholar
9Costa-Pinto, FA, Basso, AS, DeSá-Rocha, LC, Britto, LR, Russo, M, Palermo-Neto, J. Neural correlates of IgE-mediated allergy. Ann N Y Acad Sci 2006;1088:116–31CrossRefGoogle ScholarPubMed
10Tonelli, LH, Katz, M, Kovacsics, CE, Gould, TD, Joppy, B, Hoshino, A et al. Allergic rhinitis induces anxiety-like behavior and altered social interaction in rodents, Brain Behav Immun 2009;23:784–93CrossRefGoogle ScholarPubMed
11Deller, T, Orth, CB, Del Turco, D, Vlachos, A, Burbach, GJ, Drakew, A et al. A role for synaptopodin and the spine apparatus in hippocampal synaptic plasticity. Ann Anat 2007;189:5–16Google Scholar
12Frick, KM, Fernandez, SM, Bulinski, SC. Estrogen replacement improves spatial reference memory and increases hippocampal synaptophysin in aged female mice. Neuroscience 2002;115:547–58Google Scholar
13Alfarez, DN, Wiegert, O, Krugers, HJ. Stress, corticosteroid hormones and hippocampal synaptic function. CNS Neurol Disord Drug Targets 2006;5:521–9CrossRefGoogle ScholarPubMed
14Bernard, C, Cossart, R, Hirsch, JC, Esclapez, M, Ben-Ari, Y. What is GABAergic inhibition? How is it modified in epilepsy? Epilepsia 2000;41:S90–5CrossRefGoogle Scholar
15Berry, SD, Seager, MA. Hippocampal theta oscillations and classical conditioning. Neurobiol Learn Mem 2001;76:298–313Google Scholar
16Sakashita, M, Hirota, T, Harada, M, Nakamichi, R, Tsunoda, T, Osawa, Y et al. Prevalence of allergic rhinitis and sensitization to common aeroallergens in a Japanese population, Int Arch Allergy Immunol 2010;151:255–61CrossRefGoogle Scholar
17Alsowaidi, S, Abdulle, A, Shehab, A, Zuberbier, T, Bernsen, R. Allergic rhinitis: prevalence and possible risk factors in a Gulf Arab population. Allergy 2010;65:208–12CrossRefGoogle Scholar
18Bauchau, V, Durham, SR. Prevalence and rate of diagnosis of allergic rhinitis in Europe. Eur Respir J 2004;24:758–64Google Scholar
19Marshall, PS, O'Hara, C, Steinberg, P. Effects of seasonal allergic rhinitis on selected cognitive abilities. Ann Allergy Asthma Immunol 2000;84:403–10Google Scholar
20Shaaban, R. Zureik, M, Soussan, D, Neukirch, C, Heinrich, J, Sunyer, J et al. Rhinitis and onset of asthma: a longitudinal population-based study. Lancet 2008;372:1049–57CrossRefGoogle ScholarPubMed