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Natural Repressors of P-induced hybrid dysgenesis in Drosophila melanogaster: a model for repressor evolution

Published online by Cambridge University Press:  14 April 2009

P. Corish ,
D. M. Black ,
D. W. Featherston ,
J. Merriam  and
G. A. Dover
P. Corish
Affiliation:
Department of Genetics, Adrian Building, University of Leicester, University Road, Leicester LEI 7RH, UK
D. M. Black
Affiliation:
Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearden, Glasgow, Scotland
D. W. Featherston
Affiliation:
Katholieke Universiteit, 6525 ED, Nijmegen, Netherlands
J. Merriam
Affiliation:
Department of Biology, University of California, Los Angeles, 405 Hilgard Avenue, CA 90024, USA
G. A. Dover
Affiliation:
Department of Genetics, Adrian Building, University of Leicester, University Road, Leicester LEI 7RH, UK
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Type I repressors control P element transposition and comprise full length elements and elements with small 3′ deletions in the final exon. Using a sensitive assay for measuring the strength of repression of P element transposition in somatic and germline tissues, we have isolated and characterized a naturally occurring type I repressor element from a Q population of Drosophila melanogaster. We demonstrate that the almost complete repression of transposition in this population is a mixture of KP elements with intermediate levels of repression, and the strong contribution of a single 2·6 kb P element deletion derivative, which we call SR (Strong Repressor). A deletion in the final intron of SR allows for the constitutive production of a putative 75 kDa repressor protein in germline tissues in addition to the production of the 66 kDa repressor in the soma, which would result in a biparental mode of inheritance of repression. Basedon the four observed classes of natural Q populations, we propose a model in which populations containing SR-like elements, capable of producing strong type I repressor constitutively, have a selective advantage over populations which rely either on maternally transmitted P cytotype or on KPinduced weak levels of repression. Such populations may subsequently spread and constitute an evolutionary stable strategy for the repression of hybrid dysgenesis in Drosophila melanogaster.

Type
Research Article
Information
Genetics Research , Volume 67 , Issue 2 , April 1996 , pp. 109 - 121
Copyright
Copyright © Cambridge University Press 1996

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