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The natural occurring RRR-α-Tocopherol and synthetic α-Tocopherol stereoisomers in maternal plasma, cord plasma and breast milk among six regions of China
Published online by Cambridge University Press: 27 June 2022
Abstract
The study aimed to investigate RRR-α-Tocopherol and synthetic α-Tocopherol stereoisomers in maternal plasma, cord plasma and breast milk from different regions of China, providing a reference for further guidance on maternal diet and the potential need to supplement mothers with vitamin E. Two hundred and twenty-one sample sets from maternal plasma, cord plasma and three stages of milk (colostrum: 1–5 d after delivery; transitional milk: 10–15 d; mature milk: 40–45 d) were collected longitudinally in six regions of Shanghai, Guangzhou, Tianjin, Chengdu, Lanzhou and Changchun. α-Tocopherol and the stereoisomers were determined by HPLC with a fluorescence detector. The RRR configuration accounted for more than 80 % of α-Tocopherol in maternal plasma, cord plasma and breast milk. Overall, there were regional differences both in α-Tocopherol and RRR. There were significant correlations between α-Tocopherol and RRR in maternal plasma, cord plasma and milk (P < 0.001). As well as negative correlations among α-Tocopherol, RRR and weight-related indicators, which refer to pre-gestation weight and BMI, pre-delivery weight and BMI and pregnancy weight gain, in almost all of samples. This study suggested that RRR-α-Tocopherol was the dominant configuration of α-Tocopherol and the main active form of vitamin E in the early life, guiding the rational supplement of pregnant women and the addition of α-Tocopherol in infant formula milk powder.
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- Research Article
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- © The Author(s), 2022. Published by Cambridge University Press on behalf of The Nutrition Society
Footnotes
†
These authors contributed equally to this work and should be considered as co-first authors.
References
Azzi, A (2018) Many tocopherols, one vitamin E. Mol Aspects Med 61, 92–103.CrossRefGoogle ScholarPubMed
Hanson, C, Lyden, E, Furtado, J, et al. (2019) Vitamin E status and associations in maternal-infant Dyads in the Midwestern United States. Clin Nutr 38, 934–939.CrossRefGoogle ScholarPubMed
Medicine F.a.N.B.I.o. (2000) Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: The National Academy of Sciences.Google Scholar
Kuchan, MJ, Jensen, SK, Johnson, EJ, et al. (2016) The naturally occurring alpha-tocopherol stereoisomer RRR-a-tocopherol is predominant in the human infant brain. Br J Nutr 116, 126–131.CrossRefGoogle Scholar
Stimming, M, Mesch, CM, Kersting, M, et al. (2014) Vitamin E content and estimated need in German infant and follow-on formulas with and without long-chain polyunsaturated fatty acids (LC-PUFA) enrichment. J Agric Food Chem 62, 10153–10161.CrossRefGoogle ScholarPubMed
Raederstorff, D, Wyss, A, Calder, PC, et al. (2015) Vitamin E function and requirements in relation to PUFA. Br J Nutr 114, 1113–1122.CrossRefGoogle ScholarPubMed
World Health Organization (2003) Global Strategy for Infant and Young Child Feeding. Geneva: WHO.Google Scholar
Hauta-Alus, HH, Kajantie, E, Holmlund-Suila, EM, et al. (2019) High pregnancy, cord plasma, and infant vitamin D concentrations may predict slower infant growth. J Clin Endocrinol Metab 104, 397–407.CrossRefGoogle Scholar
Gaur, S, Kuchan, MJ, Lai, CS, et al. (2017) Supplementation with RRR- or all-rac-α-tocopherol differentially affects the α-tocopherol stereoisomer profile in the milk, plasma of lactating women. J Nutr 147, 1301–1307.CrossRefGoogle ScholarPubMed
Szewczyk, K, Chojnacka, A & Górnicka, M (2021) Tocopherols and tocotrienols—bioactive dietary compounds; what is certain, what is doubt? Int J Mol Sci 22, 6222.CrossRefGoogle ScholarPubMed
Clemente, HA, Ramalho, HM, Lima, MS, et al. (2015) Maternal supplementation with natural or synthetic vitamin E and its levels in human colostrum. J Pediatr Gastroenterol Nutr 60, 533–537.CrossRefGoogle ScholarPubMed
Tijerina-Saenz, A, Innis, SM & Kitts, DD (2009) Antioxidant capacity of human milk and its association with vitamins A and E and fatty acid composition. Acta Paediatr 98, 1793–1798.CrossRefGoogle Scholar
Kuchan, MJ, DeMichele, SJ, Schimpf, KJ, et al. (2021) α-Tocopherol stereoisomer profiles in matched human maternal, umbilical cord plasma. Curr Dev Nutr 5, nzab073.CrossRefGoogle Scholar
Woods, JR Jr, Cavanaugh, JL, Norkus, EP, et al. (2002) The effect of labor on maternal and fetal vitamins C and E. Am J Obstet Gynecol 187, 1179–1183.CrossRefGoogle ScholarPubMed
Fares, S, Feki, M, Khouaja-Mokrani, C, et al. (2015) Nutritional practice effectiveness to achieve adequate plasma vitamin A, E and D during the early postnatal life in Tunisian very low birth weight infants. J Matern Fetal Neonatal Med 28, 1324–1328.CrossRefGoogle Scholar
Brion, LP, Bell, EF & Raghuveer, TS (2003) Vitamin E supplementation for prevention of morbidity and mortality in preterm infants. Cochrane Database Syst Rev 4, CD003665.Google Scholar
Fares, S, Sethom, MM, Khouaja-Mokrani, C, et al. (2014) Vitamin A, E, and D deficiencies in tunisian very low birth weight neonates: prevalence and risk factors. Pediatr Neonatol 55, 196–201.CrossRefGoogle Scholar
Lima, MS, Dimenstein, R & Ribeiro, KD (2014) Vitamin E concentration in human milk and associated factors: a literature review. J Pediatr 90, 440–448.CrossRefGoogle ScholarPubMed
Ostrea, EM, Balun, JE, Winkler, R, et al. (1986) Influence of breast-feeding on the restoration of the low serum concentration of vitamin E and beta-carotene in the newborn infant. Am J Obstet Gynecol 154, 1014–1017.CrossRefGoogle ScholarPubMed
Liu, Z, Neuringer, M, Erdman, JW Jr, et al. (2019) The effects of breastfeeding versus formula-feeding on cerebral cortex maturation in infant rhesus macaques. Neuroimage 184, 372–385.CrossRefGoogle ScholarPubMed
Gaur, S, Neuringer, M, Erdman, JW Jr, et al. (2017) Supplementation with RRR- or all-rac-α-tocopherol differentially affects the a-tocopherol stereoisomer profile in the milk and plasma of lactating women. J Nutr 147, 1301–1307.CrossRefGoogle ScholarPubMed
Ranard, KM, Kuchan, MJ, Bruno, RS, et al. (2020) Synthetic α-tocopherol, compared with natural α-tocopherol, downregulates myelin genes in cerebella of adolescent ttpa-null mice. J Nutr 150, 1031–1040.CrossRefGoogle ScholarPubMed
Xue, Y, Campos-Giménez, E, Redeuil, KM, et al. (2017) Concentrations of carotenoids and tocopherols in breast milk from urban Chinese mothers and their associations with maternal characteristics: a cross-sectional study. Nutrients 9, 1229.CrossRefGoogle ScholarPubMed
de Sousa Rebouças, A, Costa Lemos da Silva, AG, Freitas de Oliveira, A, et al. (2019) Factors associated with increased alpha-tocopherol content in milk in response to maternal supplementation with 800 IU of vitamin E. Nutrients 11, 900.CrossRefGoogle ScholarPubMed
da Silva, A, de Sousa Rebouças, A, Mendonça, BM, et al. (2019) Relationship between the dietary intake, serum, and breast milk concentrations of vitamin A and vitamin E in a cohort of women over the course of lactation. Matern Child Nutr 15, e12772.CrossRefGoogle Scholar
Stone, WL, LeClair, I, Ponder, T, et al. (2003) Infants discriminate between natural and synthetic vitamin E. Am J Clin Nutr 77, 899–906.CrossRefGoogle ScholarPubMed
da Silva Ribeiro, KD, Lima, MS, Medeiros, JF, et al. (2016) Association between maternal vitamin E status and a-tocopherol levels in the newborn and colostrum. Matern Child Nutr 12, 801–807.CrossRefGoogle Scholar