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Section 7 - Other Complications of Hematopoietic Cell Transplants

Published online by Cambridge University Press:  24 May 2017

Hillard M. Lazarus
Affiliation:
Case Western Reserve University, Ohio
Robert Peter Gale
Affiliation:
Imperial College London
Armand Keating
Affiliation:
University of Toronto
Andrea Bacigalupo
Affiliation:
Ospedale San Martino, Genoa
Reinhold Munker
Affiliation:
Louisiana State University, Shreveport
Kerry Atkinson
Affiliation:
University of Queensland
Syed Ali Abutalib
Affiliation:
Midwestern Regional Medical Center, Cancer Treatment Centers of America, Chicago
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Hematopoietic Cell Transplants
Concepts, Controversies and Future Directions
, pp. 183 - 200
Publisher: Cambridge University Press
Print publication year: 2000

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References

References

Martin, PJ, Counts, GW Jr, Appelbaum, FR, et al. Life expectancy in patients surviving more than 5 years after hematopoietic cell transplantation. J Clin Oncol. 2010; 28: 1011–6.Google Scholar
Bhatia, S, Francisco, L, Carter, A, et al. Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors: report from the Bone Marrow Transplant Survivor Study. Blood. 2007; 110: 3784–92.Google Scholar
Cooke, KR, Yanik, GA. Lung injury following hematopoietic cell transplantation. In: Appelbaum, FR, Forman, SJ, Negrin, SJ, Blume, KG, eds. Thomas’ Hematopoietic Cell Transplantation , 4th edn. Malden, MA, Blackwell Publishing, 2009, pp 1456–71.Google Scholar
Panoskaltsis-Mortari, A, Griese, M, Madtes, DK, et al. An official American Thoracic Society research statement: noninfectious lung injury after hematopoietic stem cell transplantation: idiopathic pneumonia syndrome. Am J Respir Crit Care Med. 2011; 183: 1262–79.CrossRefGoogle ScholarPubMed
Carreras, E. Early complications after HSCT. In: Apperley, J, Carreras, E, Gluckman, E, Mazzi, T, eds. EBMT Handbook of Hematopoietic Stem Cell Transplantation. Genoa, Italy, Forum Service Editore, 2012, pp 177–94.Google Scholar
Lucena, CM, Torres, A, Rovira, M, et al. Pulmonary complications in hematopoietic SCT: a prospective study. Bone Marrow Transplant. 2014 Jul 21. doi:10.1038/bmt.2014.151. [Epub ahead of print] PubMed PMID: 25046219.Google Scholar
Socié, G, Salooja, N, Cohen, A, et al Nonmalignant late effects after allogeneic stem cell transplantation. Blood. 2003; 101: 3373–85.CrossRefGoogle ScholarPubMed
Flowers, MED, Deeg, HJ. Delayed non-malignant complications after hematopoietic cell transplantation. In: Appelbaum, FR, Forman, SJ, Negrin, SJ, Blume, KG, eds. Thomas’ Hematopoietic Cell Transplantation , 4th edn. Malden, MA, Blackwell Publishing, 2009, pp 1620–36.Google Scholar
Yanik, GA, Horowitz, MM, Weisdorf, DJ, et al. Randomized, double-blind, placebo-controlled trial of soluble tumor necrosis factor receptor: Enbrel (etanercept) for the treatment of idiopathic pneumonia syndrome after allogeneic stem cell transplantation: blood and marrow transplant clinical trials network protocol. Biol Blood Marrow Transplant. 2014; 20: 858–64.Google Scholar
Afessa, B, Tefferi, A, Litzow, MR, Krowka, MJ, Wylam, ME, Peters, SG. Diffuse alveolar hemorrhage in hematopoietic stem cell transplant recipients. Am J Respir Crit Care Med. 2002; 166: 641–5.Google ScholarPubMed
Majhail, NS, Parks, K, Defor, TE, Weisdorf, DJ. Diffuse alveolar hemorrhage and infection-associated alveolar hemorrhage following hematopoietic stem cell transplantation: related and high-risk clinical syndromes. Biol Blood Marrow Transplant. 2006; 12:1038–46.Google ScholarPubMed
Elinoff, JM, Bagci, U, Moriyama, B, et al. Recombinant human factor VIIa for alveolar hemorrhage following allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2014; 20: 969–78.CrossRefGoogle ScholarPubMed
Carreras, E, Diaz-Ricart M, . The role of the endothelium in the short-term complications of hematopoietic SCT. Bone Marrow Transplant. 201; 46: 1495–502.Google Scholar
Paczesny, S, Diaz-Ricart, M, Carreras, E, Cooke, KR. Translational research efforts in biomarkers and biology of early transplant-related complications. Biol Blood Marrow Transplant. 2011; 17(Suppl): S101–8.CrossRefGoogle ScholarPubMed
Penack, O, Socié, G, van den Brink, MR. The importance of neovascularization and its inhibition for allogeneic hematopoietic stem cell transplantation. Blood. 2011; 117: 4181–9.CrossRefGoogle ScholarPubMed
Carreras, E, Fernández-Avilés, F, Silva, L, et al. Engraftment syndrome alters auto-SCT: analysis of diagnostic criteria and risk factors in a large series from a single center. Bone Marrow Transplant. 2010; 45: 1417–22.CrossRefGoogle Scholar
Maiolino, A, Biasoli, I, Lima, J, et al. Engraftment syndrome following autologous hematopoietic stem cell transplantation: definition of diagnostic criteria. Bone Marrow Transplant. 2003; 31: 393–7.CrossRefGoogle ScholarPubMed
Speizer, TR. Engraftment syndrome following hematopoietic stem cell transplantation. Bone Marrow Transplant. 2001; 27: 893–8.Google Scholar
Cornell, RF, Hari, P, Zhang, MJ, et al. Divergent effects of novel immunomodulatory agents and cyclophosphamide on the risk of engraftment syndrome after autologous peripheral blood stem cell transplantation for multiple myeloma. Biol Blood Marrow Transplant. 2013; 19: 1368–73.CrossRefGoogle ScholarPubMed
Gorak, E, Geller, N, Srinivasan, R, et al. Engraftment syndrome after nonmyeloablative allogeneic hematopoietic stem cell transplantation: incidence and effects on survival. Biol Blood Marrow Transplant. 2005; 11: 542–50.Google Scholar
Hong, KT, Kang, HJ, Kim, NH, et al. Peri-engraftment syndrome in allogeneic hematopoietic SCT. Bone Marrow Transplant. 2013; 48: 523–8.CrossRefGoogle ScholarPubMed
Chang, L, Frame, D, Braun, T, et al. Engraftment syndrome after allogeneic hematopoietic cell transplantation predicts poor outcomes. Biol Blood Marrow Transplant. 2014; 20: 1407–17.CrossRefGoogle ScholarPubMed
Cho, BS, Yahng, SA, Lee, SE, et al. Validation of recently proposed consensus criteria for thrombotic microangiopathy after allogeneic hematopoietic stem-cell transplantation. Transplantation. 2010; 90: 918–26.Google Scholar
Ruutu, T, Barosi, G, Benjamin, RJ, et al. Diagnostic criteria for hematopoietic stem cell transplant-associated microangiopathy: results of a consensus process by an International Working Group. Haematologica. 2007; 92: 95100.Google Scholar
Ho, VT, Cutler, C, Carter, S, et al. Blood and Marrow Transplant Clinical Trials Network Toxicity Committee consensus summary: thrombotic microangiopathy after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2005; 11: 571–5.CrossRefGoogle ScholarPubMed
Carmona, A, Díaz-Ricart, M, Palomo, M, et al. Distinct deleterious effects of cyclosporine and tacrolimus and combined tacrolimus-sirolimus on endothelial cells: protective effect of defibrotide. Biol Blood Marrow Transplant. 2013; 19: 1439–45.Google Scholar
Laskin, BL, Goebel, J, Davies, SM, Jodele, S. Small vessels, big trouble in the kidneys and beyond: hematopoietic stem cell transplant associated-thrombotic microangiopathy. Blood. 2011; 118: 1452–62.Google Scholar
Daly, AS, Xenocostas, A, Lipton, JH. Transplantation-associated thrombotic microangiopathy: twenty-two years later. Bone Marrow Transplant. 2002; 30: 709–15.Google Scholar
Tichelli, A, Bucher, C, Rovó, A, et al., Premature cardiovascular disease after allogeneic hematopoietic stem-cell transplantation. Blood. 2007; 110: 3463–71.Google Scholar
Tichelli, A, Passweg, J, Wójcik, D, et al. Late cardiovascular events after allogeneic hematopoietic stem cell transplantation: a retrospective multicenter study of the Late Effects Working Party of the EBMT. Haematologica. 2008; 93: 1203–10.Google Scholar
Chow, EJ, Wong, K, Lee, SJ, et al. Late cardiovascular complications after hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2014; 20: 794800.Google Scholar
Baker, KS, Chow, E, Steinberger, J. Metabolic syndrome and cardiovascular risk in survivors after hematopoietic cell transplantation. Bone Marrow Transplant. 2012; 47: 619–25.CrossRefGoogle ScholarPubMed
Baker, KS, Ness, KK, Steinberger, J, et al. Diabetes, hypertension, and cardiovascular events in survivors of hematopoietic cell transplantation: a report from the bone marrow transplantation survivor study. Blood. 2007; 109: 1765–72.Google Scholar
Armenian, SH, Sun, CL, Vase, T, et al., Cardiovascular risk factors in hematopoietic cell transplantation survivors: role in development of subsequent cardiovascular disease. Blood. 2012; 120: 4505–12.Google Scholar
Majhail, NS, Rizzo, JD, Lee, SJ, et al. Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2012; 18: 348–71.Google Scholar
McDonald, GB, Sharma, P, Matthews, DE, Shulman, HM, Thomas, ED. Venocclusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisposing factors. Hepatology 1984; 4: 116–22.Google Scholar
Jones, RJ, Lee, KS, Beschorner, WE, et al. Venoocclusive disease of the liver following bone marrow transplantation. Transplantation 1987; 44: 778–83.CrossRefGoogle ScholarPubMed
Carreras, E, Grañena, A, Navasa, M, et al. On the reliability of clinical criteria for the diagnosis of hepatic veno-occlusive disease. Ann Hematol. 1993; 66: 7780.Google Scholar
Corbacioglu, S, Cesaro, S, Faraci, M, et al. Defibrotide for prophylaxis of hepatic veno-occlusive disease in paediatric haemopoietic stem-cell transplantation: an open-label, phase 3, randomised controlled trial. Lancet. 2012; 379: 1301–9.Google Scholar
Lee, JL, Gooley, T, Bensinger, W, Schiffman, K, McDonald, GB. Veno-occlusive disease of the liver after busulfan, melphalan, and thiotepa conditioning therapy: incidence, risk factors, and outcome. Biol Blood Marrow Transplant. 1999; 5: 306–15.CrossRefGoogle ScholarPubMed
Carreras, E, Fernández-Avilés, F, Silva, L, et al. Engraftment syndrome alter auto-SCT: analysis of diagnostic criteria and risk factors in a large series from a single center. Bone Marrow Transplant. 2010; 45: 1417–22.Google Scholar
Strasser, SI, McDonald, GB. Gastrointestinal and hepatic complications. In: Appelbaum, FR, Forman, SJ, Negrin, SJ, Blume, KG, eds. Thomas’ Hematopoietic Cell Transplantation , 4th edn. Malden, MA, Blackwell Publishing, 2009, pp 1434–55.Google Scholar
Coppell, JA, Richardson, PG, Soiffer, R, et al. Hepatic veno-occlusive disease following stem cell transplantation: incidence, clinical course, and outcome. Biol Blood Marrow Transplant. 2010; 16: 157–68.Google Scholar
Carreras, E, Díaz-Beyá, M, Rosiñol, L, et al. The incidence of veno-occlusive disease following allogeneic hematopoietic stem cell transplantation has diminished and the outcome improved over the last decade. Biol Blood Marrow Transplant. 2011; 17: 1713–20.CrossRefGoogle ScholarPubMed
Carreras, E, Bertz, H, Arcese, W, et al. Incidence and outcome of hepatic veno-occlusive disease after blood or marrow transplantation: a prospective cohort study of the EBMT. Blood. 1998; 92: 3599–604.Google ScholarPubMed
Soiffer, RJ, Dear, K, Rabinowe, SN, et al. Hepatic dysfunction following T-cell-depleted allogeneic bone marrow transplantation. Transplantation. 1991; 52: 1014–9.Google Scholar
Moscardó, F, Urbano-Ispizua, A, Sanz, GF, et al. Positive selection for CD34+ reduces the incidence and severity of veno-occlusive disease of the liver after HLA-identical sibling allogeneic peripheral blood stem cell transplantation. Exp Hematol. 2003; 31: 545–50.Google Scholar
Vallejo, C, Batlle, M, Vazquez, L, et al. Phase IV open-label study of the efficacy and safety of deferasirox after allogeneic stem cell transplantation. Haematologica. 2014; Jul 4. [Epub ahead of print] PubMed PMID: 24997153.Google Scholar
Hägglund, H, Remberger, M, Klaesson, S, Lönnqvist, B, Ljungman, P, Ringden, O. Norethisterone treatment, a major risk factor for veno-occlusive disease in the liver after allogeneic bone marrow transplantation. Blood. 1998; 92: 4568–72.CrossRefGoogle Scholar
Daly, A, Savoie, ML, Geddes, M, et al. Fludarabine, busulfan, antithymocyte globulin, and total body irradiation for pretransplantation conditioning in acute lymphoblastic leukemia: excellent outcomes in all but older patients with comorbidities. Biol Blood Marrow Transplant. 2012; 18: 1921–6.Google Scholar
Cantoni, N, Gerull, S, Heim, D, et al. Order of application and liver toxicity in patients given BU and CY containing conditioning regimens for allogeneic hematopoietic SCT. Bone Marrow Transplant. 2011; 46: 344–9.CrossRefGoogle ScholarPubMed
Deeg, HJ, Shulman, HM, Schmidt, E, Yee, GC, Thomas, ED, Storb, R. Marrow graft rejection and veno-occlusive disease of the liver in patients with aplastic anemia conditioned with cyclophosphamide and cyclosporine. Transplantation. 1986; 42: 497501.Google Scholar
Dignan, FL, Wynn, RF, Hadzic, N, et al. BCSH/BSBMT guideline: diagnosis and management of veno-occlusive disease (sinusoidal obstruction syndrome) following haematopoietic stem cell transplantation. Br J Haematol. 2013; 163: 444–57.CrossRefGoogle ScholarPubMed
Ruutu, T, Juvonen, E, Remberger, M, et al. Improved survival with ursodeoxycholic acid prophylaxis in allogeneic stem cell transplantation: long-term follow-up of a randomized study. Biol Blood Marrow Transplant. 2014; 20: 135–8.Google Scholar
Carreras, E. How I treat sinusoidal obstruction syndrome after hematopoietic cell transplantation. Br J Haematol. 2015; 168: 481–91.Google Scholar
Carreras, E, Grañena, A, Navasa, M, et al. Transjugular liver biopsy in BMT. Bone Marrow Transplant. 1993; 11: 21–6.Google Scholar
Hingorani, S. Kidney and bladder complications of hematopoietic cell transplantation. In: Appelbaum, FR, Forman, SJ, Negrin, SJ, Blume, KG, eds. Thomas’ Hematopoietic Cell Transplantation; 4th edn. Malden, MA, Blackwell Publishing, 2009, pp 1473–86.Google Scholar
Silva, L, Patah, PA, Saliba, RM, et al. Hemorrhagic cystitis after allogeneic hematopoietic stem cell transplants is the complex result of BK virus infection, preparative regimen intensity and donor type. Haematologica. 2010; 95: 1183–90.Google Scholar
Raiola, AM, Dominietto, A, Ghiso, A, et al. Unmanipulated haploidentical bone marrow transplantation and posttransplantation cyclophosphamide for hematologic malignancies after myeloablative conditioning. Biol Blood Marrow Transplant. 2013; 19: 117–22.Google Scholar
Shepherd, JD, Pringle, LE, Barnett, MJ, Klingemann, HG, Reece, DE, Phillips, GL. Mesna versus hyperhydration for the prevention of cyclophosphamide-induced hemorrhagic cystitis in bone marrow transplantation. J Clin Oncol. 1991; 9: 2016–20.Google Scholar
Giné, E, Rovira, M, Real, I, et al. Successful treatment of severe hemorrhagic cystitis after hemopoietic cell transplantation by selective embolization of the vesical arteries. Bone Marrow Transplant. 2003; 31: 923–5.Google Scholar
Tichelli, A, Socié, G. Late effects in patients treated with HSCT. In: Apperley, J, Carreras, E, Gluckman, E, Mazzi, T eds. EBMT Handbook of Hematopoietic Stem Cell Transplantation. Genoa, Italy, Forum Service Editore, 2012, pp 249–67.Google Scholar
Choi, M, Sun, CL, Kurian, S, et al. Incidence and predictors of delayed chronic kidney disease in long-term survivors of hematopoietic cell transplantation. Cancer. 2008; 113: 1580–7.Google Scholar
Kandeel, FR. Endocrine complications following hematopoietic cell transplantation. In: Appelbaum, FR, Forman, SJ, Negrin, SJ, Blume, KG, eds. Thomas’ Hematopoietic Cell Transplantation; 4th edn. Malden, MA, Blackwell Publishing, 2009, pp 1487–522.Google Scholar
Sanders, JE, Hoffmeister, PA, Woolfrey, AE, et al. Thyroid function following hematopoietic cell transplantation in children: 30 years’ experience. Blood. 2009; 113: 306–8.CrossRefGoogle ScholarPubMed
Sanders, JE. Growth and development after hematopoietic cell transplantation. In: Appelbaum, FR, Forman, SJ, Negrin, SJ, Blume, KG, eds, Thomas’ Hematopoietic Cell Transplantation; 4th edn. Malden, MA, Blackwell Publishing, 2009, pp 1608–16.Google Scholar
Loren, AW, Chow, E, Jacobsohn, DA, et al. Pregnancy after hematopoietic cell transplantation: a report from the late effects working committee of the Center for International Blood and Marrow Transplant Research (CIBMTR). Biol Blood Marrow Transplant. 2011; 17: 157–66.Google Scholar
Joshi, S, Savani, BN, Chow, EJ, et al. Clinical guide to fertility preservation in hematopoietic cell transplant recipients. Bone Marrow Transplant. 2014; 49: 477–84.Google Scholar
Kraus, PD, Wolff, D, Grauer, O, et al. Muscle cramps and neuropathies in patients with allogeneic hematopoietic stem cell transplantation and graft-versus-host disease. PLoS One. 2012; 7: e44922.Google Scholar

References

Bosch, M., and Storek, J.. Immune reconstitution after hematopoietic cell transplantation. Curr Opin Hematol 2012; 19:324–35.CrossRefGoogle ScholarPubMed
Savani, B. N., Adams, S., Uribe, M., et al. Rapid natural killer cell recovery determines outcome after T-cell-depleted HLA-identical stem cell transplantation in patients with myeloid leukemias but not with acute lymphoblastic leukemia. Leukemia 2007; 21:2145–52.CrossRefGoogle Scholar
Le Blanc, K., Schaffer, M., Hägglund, H., et al. Lymphocyte recovery is a major determinant of outcome after matched unrelated myeloablative transplantation for myelogenous malignancies. Biol Blood Marrow Transplant 2009; 15:1108–15.Google Scholar
Michelis, F. V., Loach, D., Uhm, J., et al. Early lymphocyte recovery at 28 d post-transplant is predictive of reduced risk of relapse in patients with acute myeloid leukemia transplanted with peripheral blood stem cell grafts. Eur J Haematol 2014; 93(4):273–80. .Google Scholar
Burke, M. J., Janardan, S. K., Brunstein, C., et al. Early lymphocyte recovery and outcomes after umbilical cord blood transplantation (UCBT) for hematologic malignancies. Biol Blood Marrow Transplant 2011; 17:831–40.Google Scholar
Komanduri, K. V., de Lima, M., McMannis, J., et al. Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing. Blood 2007; 110:4543–51.Google Scholar
Satpathy, A. T., Albring, J. C., and Murphy, K. M.. Re(de)fining the dendritic cell lineage. Nat Immunol 2012; 13:1145–54.Google Scholar
Ruggeri, L., Urbani, E., Perruccio, K., et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 2002; 295:2097–100.CrossRefGoogle ScholarPubMed
Ruggeri, L., Burchielli, E., Capanni M, M., et al. NK cell alloreactivity and allogeneic hematopoietic stem cell transplantation. Blood Cells Mol Dis 2008; 40:8490.Google Scholar
Chang, Y. J., and Huang, X. J.. Effects of the NK cell recovery on outcomes of unmanipulated haploidentical blood and marrow transplantation for patients with hematologic malignancies. Biol Blood Marrow Transplant 2008; 14:323–34.Google Scholar
Della Chiesa, M., Muccio, L., Bertaina, A., et al. Impact of HCMV infection on NK cell development and function after HCT. Front Immunol 2013; 4:458.Google Scholar
Gudiol, C., Arnan, M., Sánchez-Ortega, I., et al. Etiology, clinical features and outcomes of pre-engraftment and post-engraftment bloodstream infection in hematopoietic SCT recipients. Bone Marrow Transplant 2014; 49:824−30.Google Scholar
Mackall, C., Gress, R., Peggs, K., et al; Center for International Blood and Marrow Transplant Research (CIBMTR); National Marrow Donor Program (NMDP); European Blood and Marrow Transplant Group (EBMT); American Society of Blood and Marrow Transplantation (ASBMT); Canadian Blood and Marrow Transplant Group (CBMTG); Infectious Disease Society of America (IDSA); Society for Healthcare Epidemiology of America (SHEA); Association of Medical Microbiology and Infectious Diseases Canada (AMMI); Centers for Disease Control and Prevention (CDC). Background to hematopoietic cell transplantation, including post transplant immune recovery. Bone Marrow Transplant 2009; 44:457–62.Google Scholar
Fozza, C.. T-cell receptor repertoire usage in hematologic malignancies. Crit Rev Oncol Hematol 2013; 86:201–11.Google Scholar
Kim, D. H., Won, D. I., Lee, N. Y., et al. Rapid helper T-cell recovery above 200 x 10 6/l at 3 months correlates to successful transplant outcomes after allogeneic stem cell transplantation. Bone Marrow Transplant 2006; 37:1119–28.Google Scholar
Fedele, R., Garreffa, C., Messina, G., et al. The impact of early CD4+ lymphocyte recovery on the outcome of patients who undergo allogeneic bone marrow or peripheral blood stem cell transplantation. Blood Transfus 2012; 10:174–80.Google Scholar
Six A, A., Chaara, W., Magadan, S., et al. The past, present, and future of immune repertoire biology − the rise of next-generation repertoire analysis. Front Immunol 2013; 4:413.Google ScholarPubMed
Krenger, W., and Holländer, G. A.. Thymic T-cell development in allogeneic stem cell transplantation. Blood 2011; 117:6758–76.Google Scholar
Ringhoffer, S., Döhner, H., Bunjes, D., et al. T-cell reconstitution after allogeneic stem cell transplantation: assessment by measurement of the sjTREC/βTREC ratio and thymic naive T cells. Haematologica 2013; 98:1600–8.Google Scholar
Toubert, A., Douay, C., and Clave, E.. Thymus and immune reconstitution after allogeneic hematopoietic stem cell transplantation in humans: never say never again. Tissue Antigens 2012; 79:83–9.Google Scholar
Rueff, J., Heim, D., Passweg, J., et al. Lymphocyte subset recovery and outcome after autologous hematopoietic stem cell transplantation for plasma cell myeloma. Biol Blood Marrow Transplant 2014; 20:869–9.Google Scholar
Muraro, P., Malhotra, S., Howell, M., et al. T cell repertoire following autologous stem cell transplantation for multiple sclerosis. J Clin Invest 2014; 124:1168–72.Google Scholar
Ciurea, S. O., Saliba, R. M., Bayraktar, U. D., et al. Improved early outcomes using a T cell replete graft compared with T cell depleted haploidentical hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2012; 18:1835–44.Google Scholar
Chevallier, P., Illiaquer, M., Esbelin, J., et al. Characterization of various blood and graft sources: a prospective series. Transfusion 2013; 53:2020–6.Google Scholar
Escalón, M. P.. Cord blood transplantation: evolving strategies to improve engraftment and immune reconstitution. Curr Opin Oncol 2010; 22:122–9.Google Scholar
Gärtner, F., Finke, J., and Bertz, H.. Lowering the alemtuzumab dose in reduced intensity conditioning allogeneic hematopoietic cell transplantation is associated with a favorable early intense natural killer cell recovery. Cytotherapy 2013; 15:1237–44.Google Scholar
Streitz, M., Kapinsky, M., Reed, M., et al. Standardization of whole blood immune phenotype monitoring for clinical trials: panels and methods from the ONE study. Transplant Res 2013; 2:17.Google Scholar

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