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An HLA and family study of Alzheimer's disease

Published online by Cambridge University Press:  09 July 2009

E. B. Renvoize
E. B. Renvoize*
Affiliation:
From the Department of Psychiatry, University of Leeds
*
1Address for correspondence: Dr E. B.Renvoize, Bootham Park Hospital, York Y03 7BY.
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Synopsis

Histocompatibility antigens were examined in 124 patients with Alzheimer's disease (AD), and the frequency of HLA-B15 was found to be significantly increased over controls. Pooling of data from the present and similar studies suggests that AD is not strongly associated with any particular HLA antigen, although there may be a weak association with HLA-A2, B15 and Cw3. In a family study of 34 patients with AD, secondary cases of AD were identified in 9·7% of the first-degree relatives, and cases of presenile dementia and senile dementia of the Alzheimer type were found to occur within individual families.

Type
Research Article
Information
Psychological Medicine , Volume 14 , Issue 3 , August 1984 , pp. 515 - 520
Copyright
Copyright © Cambridge University Press 1984

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References

REFERENCES

Bender, K., Mayerova, A., Klotzbucher, B., Burṙckhardt, K. & Hiller, C. (1976). No indication of postnatal selection at the HL-A loci. Tissue Antigens 7, 118–121.CrossRefGoogle ScholarPubMed
Cohen, D., Zeller, E., Eisdorfer, C. & Walford, R. L. (1979). Alzheimer's disease and the main histocompatibility complex (HLA system). Gerontologist 19, 57.Google Scholar
Constantinidis, J. (1978). Is Alzheimer's disease a major form of senile dementia? Clinical, anatomical and genetic data. In Alzheimer's Disease: Senile Dementia and Related Disorders (ed. Katzman, R., Terry, R. D. and Bick, K. L.), pp. 15–25. Raven Press: New York.Google Scholar
Corsellis, J. A. N. (1962). Mental Illness and the Ageing Brain. Oxford University Press: London.Google Scholar
Cudworth, A. G. & Festenstein, H. (1978). HLA genetic heterogeneity in diabetes mellitus. British Medical Bulletin 34, 285–289.CrossRefGoogle ScholarPubMed
Hansen, H. E., Sparck, J. V. & Larsen, S. O. (1977). An examination of HLA frequencies in three age groups. Tissue Antigens 10, 49–55.CrossRefGoogle ScholarPubMed
Henschke, P. J., Bell, D. A. & Cape, R. D. T. (1978). Alzheimer's disease and HLA. Tissue Antigens 12, 132–135.CrossRefGoogle ScholarPubMed
Heston, L. L. & Mastri, A. R. (1977). The genetics of Alzheimer's disease: associations with haematologic malignancy and Down's syndrome. Archives of General Psychiatry 34, 976–981.CrossRefGoogle ScholarPubMed
Hiller, C., Bischoff, M., Schmidt, A. & Bender, K. (1978). Analysis of the HLA-ABC linkage disequilibrium: decreasing strength of gametic association with increasing map distance. Human Genetics 41, 301–312.CrossRefGoogle ScholarPubMed
Ishii, T. & Haga, S. (1976). Immuno-electron microscopic localization of immunoglobulins in amyloid fibrils of senile plaques. Acta Neuropathologica 36, 243–249.CrossRefGoogle ScholarPubMed
Ishii, T., Haga, S. & Shimizu, F. (1975). Identification of components of immunoglobulins in senile plaques by means of fluorescent antibody technique. Acta Neuropathologica 32, 157–162.CrossRefGoogle ScholarPubMed
Joysey, V. C. & Wolf, E. (1978). HLA-A, -B and -C antigens, their serology and cross-reaction. British Medical Bulletin 34, 217–222.CrossRefGoogle Scholar
Larsson, T., Sjögren, T. & Jacobson, G. (1963). Senile dementia. A clinical, sociomedical and genetic study. Acta Psychiatrica Scandinavica 39, Suppl. 167.Google Scholar
Majsky, A., Korinkova, P., Fortynova, J., Abrahamova, J. & Vojtechovsky, M. (1981). Some critical remarks on the problem of HLA association with disease. Folia Haemalologica (Leipzig) 108, 386–391.Google ScholarPubMed
Mayr, W. R. (1975). The SD-3 locus of the HLA system with special references to T5. In Histocompatibility Testing (ed. Kissmeyer-Nielsen, F.), pp. 330–335. Munksgaard: Copenhagen.Google Scholar
Pentland, B., Christie, J. E., Watson, K. C. & Yap, P. L. (1982). Immunological parameters in Alzheimer's pre-senile dementia. Acta Psychiatrica Scandinavica 65, 375–379.CrossRefGoogle ScholarPubMed
Reed, E., Thompson, D., Mayeaux, R. & Suciu-Foca, N. (1983). HLA antigens in Alzheimer's disease. Tissue Antigens 21, 164–167.CrossRefGoogle ScholarPubMed
Reisner, E., Heyman, A., Weinberg, T., Dawson, D. & Ciftan, E. (1983). Lack of association between Alzheimer's disease and histocompatibility antigens. Tissue Antigens 21, 31–34.CrossRefGoogle ScholarPubMed
Renvoize, E. B., Hambling, M. H., Pepper, M. D. & Rajah, S. M. (1979). Possible association of Alzheimer's disease with HLA-Bw 15 and cytomegalovirus infection. Lancet i, 1238.CrossRefGoogle Scholar
Roth, M. (1971). Classification and aetiology in mental disorders of old age: some recent developments. In Recent Developments in Psychogeriatrics (ed. Kay, D. W. K. and Walk, A.), pp. 1–18. British Journal of Psychiatry Special Publication No. 6. Headley Brothers: Ashford, Kent.Google Scholar
Sim, M. (1979). Early diagnosis of Alzheimer's disease. In Alzheimer's Disease. Early Recognition of Potentially Reversible Deficits (ed. Glen, A. I. M. and Whalley, L. J.), pp. 78–85. Churchill Livingstone: Edinburgh.Google Scholar
Sjögren, T., Sjögren, H. & Lindgren, A. G. H. (1952). Morbus Alzheimer and Morbus Pick. A genetic, clinical and patho-anatomical study. Acta Psychiatrica Scandinavica Suppl. 82.Google Scholar
Slater, E. & Cowie, V. (1971). Senescence, senile and pre-senile dementias. In The Genetics of Mental Disorders (ed. Slater, E. and Cowie, V.), pp. 122–159. Oxford University Press: London.Google Scholar
Snowden, P. R., Woodrow, J. C. & Copeland, J. R. M. (1981). HLA antigens in senile dementia and multiple infarct dementia. Age and Ageing 10, 259–263.CrossRefGoogle ScholarPubMed
Sulkava, R., Koskimies, S., Wikstrom, J. & Palo, J. (1980). HLA antigens and Alzheimer's disease, Tissue Antigens 16, 191–194.CrossRefGoogle Scholar
Todorov, A. B., Go, R. C. P., Constantinidis, J. & Elston, R. C. (1975). Specificity of the clinical diagnosis of dementia. Journal of the Neurological Sciences 26, 81–98.CrossRefGoogle ScholarPubMed
Walford, R. L. & Hodge, S. E. (1980). HLA distribution in Alzheimer's disease. In Histocompatibility Testing (ed. Terasaki, P. I.), pp. 727–729. UCLA Tissue Typing Laboratory: Los Angeles.Google Scholar
Whalley, L. J., Urbaniak, S. J., Darg, C., Peutherer, J. F. & Christie, J. E. (1980). Histocompatibility antigens and antibodies to viral and other antigens in Alzheimer pre-senile dementia. Acta Psychiatrica Scandinavica 61, 1–7.CrossRefGoogle ScholarPubMed
Wilcox, C. B., Caspary, E. A. & Behan, P. O. (1980). Histocompatibility antigens in Alzheimer's disease. A preliminary study. European Neurology 19, 262–265.CrossRefGoogle ScholarPubMed
Woolf, B. (1955). On estimating the relation between blood group and disease. Annals of Human Genetics 19, 251–253.CrossRefGoogle ScholarPubMed