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Significance of advanced haemostasis investigation in recurrent, severe post-tonsillectomy bleeding

Published online by Cambridge University Press:  12 May 2011

G Kontorinis*
Affiliation:
Otorhinolaryngology Department, Hanover Medical University, Germany
B Schwab
Affiliation:
Otorhinolaryngology Department, Hanover Medical University, Germany
*
Address for correspondence: Dr Georgios Kontorinis, Otorhinolaryngology Department, Hanover Medical University, Carl Neuberg Str 1, 30625 Hanover, Germany E-mail: Kontorinis.Georgios@mh-hannover.de

Abstract

Objective:

To evaluate the significance of advanced post-operative haemostasis investigation in cases of recurrent, severe post-tonsillectomy bleeding.

Materials and methods:

Of the 120 patients treated at our tertiary centre between 2006 and 2010 due to post-tonsillectomy haemorrhage, 22 with recurrent, severe episodes of bleeding underwent further, advanced haemostasis investigation.

Results:

Underlying haemorrhagic disease was not diagnosed in any case. Isolated abnormal clotting factor levels were identified in two patients. Decreased fibrinogen concentration due to dilutional coagulopathy was found in nine cases (40.9 per cent).

Conclusion:

Recurrent, severe post-tonsillectomy haemorrhage is rarely related to undiagnosed haemostatic disorders. Thus, advanced haemostasis studies have little therapeutic relevance. However, repetitive post-tonsillectomy bleeding may be related to decreased fibrinogen levels due to dilutional coagulopathy. Therefore, fibrinogen concentration should be tested, and dilutional coagulopathy treated promptly.

Type
Main Articles
Copyright
Copyright © JLO (1984) Limited 2011

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References

1Rodriguez, KD, Sun, GH, Pike, F, Mandel, EM, Casselbrant, ML, Chi, DH. Post-tonsillectomy bleeding in children with von Willebrand disease: a single-institution experience. Otolaryngol Head Neck Surg 2010;142:715–21CrossRefGoogle ScholarPubMed
2Mattila, PS, Tahkokallio, O, Tarkkanen, J, Pitkäniemi, J, Karvonen, M, Tuomilehto, J. Causes of tonsillar disease and frequency of tonsillectomy operations. Arch Otolaryngol Head Neck Surg 2001;127:3744CrossRefGoogle ScholarPubMed
3Krishna, P, Lee, D. Post-tonsillectomy bleeding: a meta-analysis. Laryngoscope 2001;111:1358–61CrossRefGoogle ScholarPubMed
4Asaf, T, Reuveni, H, Yermiahu, T, Leiberman, A, Gurman, G, Porat, A et al. The need for routine pre-operative coagulation screening tests (prothrombin time PT/partial thromboplastin time PTT) for healthy children undergoing elective tonsillectomy and/or adenoidectomy. Int J Pediatr Otorhinolaryngol 2001;61:217–22CrossRefGoogle ScholarPubMed
5Hartnick, CJ, Ruben, RJ. Preoperative coagulation studies prior to tonsillectomy. Arch Otolaryngol Head Neck Surg 2000;126:684–6CrossRefGoogle ScholarPubMed
6Academy of Otolaryngology-Head and Neck Surgery. Clinical Indicators Compendium. Alexandria, Virginia: American Academy of Otolaryngology-Head and Neck Surgery, 1999Google Scholar
7Wieland, A, Belden, L, Cunningham, M. Preoperative coagulation screening for adenotonsillectomy: a review and comparison of current physician practices. Otolaryngol Head Neck Surg 2009;140:542–7CrossRefGoogle ScholarPubMed
8Hoffman, R. Hematology Basic Principles and Practice, 3rd edn.Philadelphia, PA: Churchill Livingston, 2000;1841–50Google Scholar
9Koscielny, J, Ziemer, S, Radtke, H, Schmutzler, M, Kiesewetter, H, Salama, A et al. A practical concept for preoperative identification of patients with impaired primary hemostasis. Clin Appl Thromb Hemost 2004;10:195204CrossRefGoogle ScholarPubMed
10Peyvandi, F, Kaufman, RJ, Seligsohn, U, Salomon, A, Bolton-Maggs, PH, Spreafico, M et al. Rare bleeding disorders. Haemophilia 2006;12:137–42CrossRefGoogle ScholarPubMed
11Mannucci, PM. Treatment of von Willebrand's disease. N Engl J Med 2004;351:683–94CrossRefGoogle ScholarPubMed
12Zwack, GC, Derkay, CS. The utility of preoperative hemostatic assessment in adenotonsillectomy. Int J Pediatr Otorhinolaryngol 1997;39:6776Google Scholar
13Lillicrap, D, Nair, SC, Srivastava, A, Rodeghiero, F, Pabinger, I, Federici, AB. Laboratory issues in bleeding disorders. Haemophilia 2006;12:6875CrossRefGoogle ScholarPubMed
14Jackson, CM, White, GC 2nd, Barrowcliffe, T, Esnouf, MP, Jespersen, J, Kluft, C et al. A reference system approach to future standardization of laboratory tests for hemostasis. A position paper of the Joint Committee of the IFCC Scientific Division and the ISTH Scientific and Standardization Committee. Thromb Haemost 2002;87:165–9Google Scholar
15Kozek-Langenecker, SA. Perioperative coagulation monitoring. Best Pract Res Clin Anaesthesiol 2010;24:2740CrossRefGoogle ScholarPubMed
16Levy, JH. Pharmacologic methods to reduce perioperative bleeding. Transfusion 2008;48(Suppl 1):31–8SGoogle Scholar
17Allen, GC, Armfield, DR, Bontempo, FA, Kingsley, LA, Goldstein, NA, Post, JC. Adenotonsillectomy in children with von Willebrand disease. Arch Otolaryngol Head Neck Surg 1999;125:547–51CrossRefGoogle ScholarPubMed
18Innerhofer, P, Kienast, J. Principles of perioperative coagulopathy. Best Pract Res Clin Anaesthesiol 2010;24:114CrossRefGoogle ScholarPubMed
19Ciavarella, D, Reed, RL, Counts, RB, Baron, L, Pavlin, E, Heimbach, DM et al. Clotting factor levels and the risk of diffuse microvascular bleeding in the massively transfused patient. Br J Haematol 1987;67:365–8CrossRefGoogle ScholarPubMed
20Fenger-Eriksen, C, Tønnesen, E, Ingerslev, J, Sørensen, B. Mechanisms of hydroxyethyl starch-induced dilutional coagulopathy. J Thromb Haemost 2009;7:1099–105Google Scholar
21Heindl, B. Perioperative coagulation monitoring – medical and economic aspects (in German). Anasthesiol Intensivmed Notfallmed Schmerzther 2010;45:292–6CrossRefGoogle Scholar
22Thaha, MA, Nilssen, EL, Holland, S, Love, G, White, PS. Routine coagulation screening in the management of emergency admission for epistaxis: is it necessary? J Laryngol Otol 2000;114:3840Google Scholar
23Awan, MS, Iqbal, M, Imam, SZ. Epistaxis: when are coagulation studies justified? Emerg Med J 2008;25:156–7Google Scholar
24Howells, RC 2nd, Wax, MK, Ramadan, HH. Value of preoperative prothrombin time/partial thromboplastin time as a predictor of postoperative hemorrhage in pediatric patients undergoing tonsillectomy. Otolaryngol Head Neck Surg 1997;117:628–32CrossRefGoogle ScholarPubMed