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Seroprevalence of hepatitis B and C in a Merseyside hospital for the mentally handicapped

Published online by Cambridge University Press:  15 May 2009

S. J. Cunningham ,
R. Cunningham ,
M. G. A. Izmeth ,
B. Baker  and
C. A. Hart
S. J. Cunningham
Affiliation:
Greaves Hall Hospital, Banks, Southport, UK
R. Cunningham
Affiliation:
Department of Medical Microbiology, Royal Liverpool University Hospital, Liverpool L7 8XP
M. G. A. Izmeth
Affiliation:
Greaves Hall Hospital, Banks, Southport, UK
B. Baker
Affiliation:
Department of Medical Microbiology, Royal Liverpool University Hospital, Liverpool L7 8XP
C. A. Hart
Affiliation:
Department of Medical Microbiology, Royal Liverpool University Hospital, Liverpool L7 8XP
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Summary

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This study reports the prevalence of antibodies to hepatitis B virus (HBV) and C virus (HCV). and the frequency of potential exposure to these viruses among patients and staff in six long-stay wards of a hospital caring for mentally handicapped adults from the Mersey region. A retrospective survey of risk behaviour among 134 patients and questionnaire survey of 75 nursing staff was performed. Serum samples from both groups were tested for HBV markers and patient sera for antibodies to HCV by enzyme-linked immunosorbent assay (ELISA). None of the 102 patients tested had antibodies against HCV. although 17 had detectable antibody to HBV core (anti-HBc). Seven out of the 17 were positive for HBV surface antigen. None was positive for IgM antibody to HBV core. Only 1 out of 61 staff had anti-HBc and none was positive for surface antigen. Twenty-nine of 75 (39%) staff reported bites sufficient to break the skin and 52 (69%) significant other injuries from patients; 25 (31%) of staff had not received HBV vaccination. None of the patients had received HBV vaccine.

We conclude that HCV does not appear to be a major hazard in this closed community but the prevalence of HBV markers indicating past exposure among patients is high, vaccine uptake is incomplete and incidents which may allow viral transmission are frequent.

Type
Research Article
Information
Epidemiology & Infection , Volume 112 , Issue 1 , February 1994 , pp. 195 - 200
Copyright
Copyright © Cambridge University Press 1994

References

REFERENCES

Holt, PA, Goodall, B, Lees, EM, Hambling, MH. Prevalence of hepatitis B markers in patients and staff in a hospital for the mentally handicapped. J Hosp Infect 1986; 7: 26–33.CrossRefGoogle Scholar
Thompson, RG, Rawlins, MD, James, OFW, Tyrer, SP, Codd, A. Low prevalence of hepatitis B in a mental handicap hospital. Lancet 1989; i: 44–5.CrossRefGoogle Scholar
Breuer, B, Friedman, SM, Millner, ES, Kane, MA, Snyder, RH, Maynard, JE. Transmission of hepatitis virus to classroom contacts of mentally retarded carriers. JAMA 1985; 254: 3190–5.CrossRefGoogle ScholarPubMed
McGregor, MA, Cowie, VA, Wassef, E, Veasey, D, Munro, J. Hepatitis B in a hospital for the mentally subnormal in south Wales. J Ment Def Res 1988; 32: 75–7.Google Scholar
Kingham, JGC, McGuire, M, Paine, DHD, Wright, R. Hepatitis B in a hospital for the mentally subnormal in southern England. BMJ 1978; ii: 594–6.CrossRefGoogle Scholar
Department of Health. Caring for people, community care in the next decade and beyond. London: HMSO. 1989.Google Scholar
Mortimer, PP, Cohen, BJ, Litton, PA, et al. , Hepatitis C virus antibody. Lancet 1989; i: 798.CrossRefGoogle Scholar
Levinson, WM, Wormser, GP, Forseter, G, Calmann, M.O'Brien, TA. Hepatitis C virus seroprevalence in the developmentally disabled. Arch Intern Med 1992; 152: 2309–11.CrossRefGoogle ScholarPubMed
Chaudhary, RK, Perry, E, Hicks, F, MacLean, C, Morbey, M. Hepatitis B and C infection in an institution for the developmentally handicapped. New Eng J Med 1992; 327: 1953.Google Scholar
Department of Health. Immunisation against infectious disease. London: HMSO, 1990.Google Scholar
Stehr-Green, P, Wilson, N, Miller, J, Lawther, A. Risk factors for hepatitis B at a residential institution for intellectually handicapped persons. NZ Med J 1991; 104: 514–6.Google Scholar
Maclennan, S, Barbara, JA, Hewitt, P, Moore, C, Contreras, M. Screening blood donations for HCV. Lancet 1992; 339: 131–2.CrossRefGoogle ScholarPubMed
Martinez, JL, del, Hierro J, Camarero, A, Medarde, A, Lopez, MT, Latasa, J. Hepatitis C virus infection in different risk groups and among blood donors. Enferm Infect Microbiol Clin 1991; 9: 345–50.Google ScholarPubMed