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Cerebellar Ataxia Produced by 3-Acetyl Pyridine in Rat

Published online by Cambridge University Press:  18 September 2015

R. F. Butterworth ,
E. Hamel ,
F. Landreville  and
A. Barbeau
R. F. Butterworth
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
E. Hamel
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
F. Landreville
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
A. Barbeau*
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
*
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
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Summary:

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A single intraperitoneal injection of 3-acetyl pyridine produces, within 24 hours of administration, signs of cerebellar ataxia and damage to the medulla oblongata and to the climbing fibers of the cerebellum. These changes are accompanied by changes in the concentration of certain amino acids in the appropriate areas. Glutamic acid is decreased in cerebellum, medulla, cortex, striatum, hippocampus, retina and olfactory bulbs, while taurine is specifically decreased in the cerebellum and medulla oblongata and aspartic acid in the retina. The concentrations of GABA and glycine are not modified in any of the areas studied. Glutamine is generally increased in concentration in areas of cell damage.

Type
Quebec Cooperative Study of Friedreich's Ataxia
Information
Canadian Journal of Neurological Sciences , Volume 5 , Issue 1 , February 1978 , pp. 131 - 133
Copyright
Copyright © Canadian Neurological Sciences Federation 1978

References

REFERENCES

Desclin, J.C. and Escubi, J. (1974). Effects of 3-acetyl pyridine on the central nervous system of the rat, as demonstrated by silver methods. Brain Res., 77, 349–363.CrossRefGoogle Scholar
Guidotti, A., Biggio, G. and Costa, E. (1975). 3-Acetyl pyridine: a tool to inhibit the tremor and the increase of cGMP content in cerebellar cortex elicited by harmaline. Brain Res., 96, 201–205.CrossRefGoogle Scholar
Holmes, G. (1907). A form of familial degeneration of cerebellum. Brain, 30, 466–471.CrossRefGoogle Scholar
Joseph, M. H. and Halliday, J. (1975). A dansylation microassay for some amino acids in brain. Anal. Biochem., 64, 389–402.CrossRefGoogle ScholarPubMed
Misra, C. H. and Olney, J. W. (1975). Cysteine oxidase in brain. Brain Res., 97, 117–126.CrossRefGoogle ScholarPubMed
Nadi, N. S., Kanter, D., McBride, W. J. and Aprison, M. H. (1977). Effects of 3-acetyl pyridine on several putative neurotransmitter amino acids in the cerebellum and medulla of the rat. J. Neurochem., 28, 661–662.CrossRefGoogle Scholar
Perry, T. L. Currier, R. D., Hansen, S. and MacLean, J. (1977). Aspartate-taurine imbalance in dominantly inherited olivopontocerebellar atrophy. Neurology, 27, 257–261.CrossRefGoogle ScholarPubMed
Perry, T. L., MacLean, J., Perry, T. L. Jr., and Hansen, S. (1976). Effects of 3-acetyl pyridine on putative neurotransmitter amino acids in rat cerebellum. Brain Res., 109, 632–635.CrossRefGoogle Scholar
Simontov, R., Snyder, S. H. and Oster-Granite, M. L. (1976). Harmaline-induced tremor in the rat; abolition by 3-acetyl pyridine destruction of cerebellar climbing fibers. Brain Res., 114, 144–151.CrossRefGoogle Scholar