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Long term pathological sequelae of neonatal endotracheal intubation

Published online by Cambridge University Press:  29 June 2007

S. J. Gould  and
J. Graham
S. J. Gould*
Affiliation:
Department of Histopathology, University College and Middlesex School of Medicine, Rockefeller Building, University Street, London WC1E 6JJ
J. Graham
Affiliation:
Department of Ear, Nose and Throat Surgery, Royal Ear Hospital, University College Hospital, Capper Street, London WC1E 6JJ.
*
Dr. S. J. Gould, Department of Histopathology, University College and Middlesex School of Medicine, Rockefeller Building, University Street, London WC1E 6JJ.
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Abstract

In neonates, acquired subglottic stenosis (SGS) is the most serious long term complication of endotracheal intubation. In this case report, we describe the pathological changes in the larynx of a child who died two years after successful treatment, involving corrective surgery, for neonatally acquired SGS. Stenosis, due to dense fibrous connective tissue, was still present at death. However, there was evidence that there had been growth of the laryngeal cartilages. Disruption of the laryngeal cartilages was present anteriorly due to the antecedent surgery but major cricoid cartilage injury secondary to intubation was not seen. The crico-arytenoid joints demonstrated ankylosis and to this was attributed the abnormal quality of voice noted in the child at follow-up. The pathological changes are considered in relation to the pathology of endotracheal intubation and pathogenesis of acquired subglottic stenosis.

Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 103 , Issue 6 , June 1989 , pp. 622 - 625
Copyright
Copyright © JLO (1984) Limited 1989

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