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The Vi antigen of Salmonella paratyphi B

Published online by Cambridge University Press:  15 May 2009

A. Felix
A. Felix
Affiliation:
From the Central Enteric Reference Laboratory and Bureau, Public Health Laboratory Service (Medical Research Council), London
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1. Salmonella paratyphi B possesses a Vi antigen essentially similar to the Vi antigens of Salm. typhi and Salm. paratyphi A.

2. The biological function of the Vi antigen of Salm. paratyphi B is to protect the O antigen against the action of the natural or immune O antibody, thereby increasing the virulence of the microorganism.

3. The most suitable paratyphoid-B vaccine strains are those that develop both the Vi and the O antigens in maximum quantities. The methods of testing vaccine strains of Salm. paratyphi B are essentially the same as those applied to the virulent Vi+O form of Salm. typhi.

4. Evidence is brought to show that Kauffmann's conclusion that Salm. paratyphi B does not develop Vi antigen is unfounded. The so-called O-factors V and V obviously cannot be classified as O antigens.

5. It is suggested that the symbol V of the Kauffmann-White schema be abandoned and this antigenic component be classed as the Vi antigen of Salm. paratyphi B.

Type
Research Article
Information
Journal of Hygiene , Volume 50 , Issue 4 , December 1952 , pp. 550 - 557
Copyright
Copyright © Cambridge University Press 1952

References

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