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F-prime factor formation in E. coli K12

Published online by Cambridge University Press:  14 April 2009

John Scaife
John Scaife
Affiliation:
Medical Research Council Microbial Genetics Research Unit, Hammersmith Hospital, London, W.12
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A model for F-prime formation is presented. It predicts that an Hfr strain giving rise to an F-prime factor would acquire a deletion corresponding to the chromosomal fragment carried by the episome. Genetic studies have confirmed this prediction. Concomitant transfer to the episome of a gene determining a function vital to the cell has permitted selection of derived Hfr strains in which the episomal fragment has been translocated to various sites on the bacterial chromosome.

Type
Research Article
Information
Genetics Research , Volume 8 , Issue 2 , September 1966 , pp. 189 - 196
Copyright
Copyright © Cambridge University Press 1966

References

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