Hostname: page-component-848d4c4894-75dct Total loading time: 0 Render date: 2024-05-08T04:48:46.445Z Has data issue: false hasContentIssue false
  • English
  • Français

A system generating spontaneous intrachromosomal changes at mitosis in Aspergillus nidulans

Published online by Cambridge University Press:  14 April 2009

B. H. Nga  and
J. A. Roper
B. H. Nga
Affiliation:
Department of Genetics, University of Sheffield
J. A. Roper
Affiliation:
Department of Genetics, University of Sheffield
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Previous studies had shown that haploid strains of Aspergillus nidulans which have a chromosome segment in duplicate are unstable at mitosis. Through the study of various haploid and diploid strains, with and without translocations and with balanced and unbalanced genomes, it has been shown: (1) that imbalance of chromosome segments is responsible for instability, and (2) that the chromosomal deletions produced are confined solely or largely to the segments which provoke instability.

The term ‘mitotic non-conformity’ has been proposed for this instability phenomenon. An explanation for it has been sought in terms of attachment sites, limited in number and specific for chromosome segments, at which replication is initiated.

Type
Research Article
Information
Genetics Research , Volume 14 , Issue 1 , August 1969 , pp. 63 - 70
Copyright
Copyright © Cambridge University Press 1969

References

REFERENCES

Bainbridge, B. W. & Roper, J. A. (1966). Observations on the effects of a chromosome duplication in Aspergillus nidulans. J. gen. Microbiol. 42, 417–424.CrossRefGoogle ScholarPubMed
Ball, C. (1967). Chromosomal instability related to gene suppression in Aspergillus nidulans. Genet. Res. 10, 173–183.CrossRefGoogle Scholar
Beermann, S. (1966). A quantitative study of chromatin diminution in embryonic mitoses of Cyclops furcifer. Genetics 54, 567–576.CrossRefGoogle ScholarPubMed
Burns, J. A. & Gerstel, D. U. (1967). Flower color variegation and instability of a block of heterochromatin in Nicotiana. Genetics 57, 155–167.CrossRefGoogle ScholarPubMed
Clutterbuck, A. J. (1968). A variegated position effect in Aspergillus nidulans. Heredity 23, 165.Google Scholar
Käfer, E. (1961). The processes of spontaneous recombination in vegetative nuclei of Aspergillus nidulans. Genetics 46, 1581–1609.CrossRefGoogle ScholarPubMed
Lhoas, P. (1961). Mitotic haploidization by treatment of Aspergillus niger diploids with p-fluorophenylalanine. Nature, Lond. 190, 744.CrossRefGoogle Scholar
Lhoas, P. (1968). Growth rate and haploidization of Aspergillus niger on medium containing p-fluorophenylalanine. Genet. Res. 12, 305–315.CrossRefGoogle ScholarPubMed
McCully, K. S. & Forbes, E. (1965). The use of p-fluorophenylalanine with ‘master-strains’ of Aspergillus nidulans for assigning genes to linkage groups. Genet. Res. 6, 352–359.CrossRefGoogle ScholarPubMed
Morpurgo, G. (1961). Somatic segregation induced by p-fluorophenylalanine. Aspergillus Newsletter 2, 10.Google Scholar
Nga, B. H. & Roper, J. A. (1968 a). Quantitative intrachromosomal changes arising at mitosis in Aspergillus nidulans. Genetics 58, 193–209.CrossRefGoogle ScholarPubMed
Nga, B. H. & Roper, J. A. (1968 b). Mitotic instability in duplication strains of Aspergillus nidulans: lethal deletions. Heredity 23, 626–627.Google Scholar
Pontecorvo, G., Roper, J. A., Hemmons, L. M., Macdonald, K. D. & Bufton, A. W. J. (1953). The genetics of Aspergillus nidulans. Adv. Genet. 5, 141–238.CrossRefGoogle ScholarPubMed
Phitchard, R. H. (1956). A genetic investigation of some adenine-requiring mutants of Aspergillus nidulans. Ph.D. thesis, Glasgow University.Google Scholar
Pritchard, R. H. (1960). The bearing of recombination analysis at high resolution on genetic fine structure in Aspergillus nidulans and the mechanism of recombination in higher organisms. In Microbial Genetics. Symp. Soc. gen. Microbiol. 10, 155–180.Google Scholar
Roper, J. A. (1952). Production of heterozygous diploids in filamentous fungi. Experientia 8, 14–15.CrossRefGoogle ScholarPubMed
Rosenberger, R. F. & Kessel, M. (1968). Nonrandom sister chromatid segregation and nuclear migration in hyphae of Aspergillus nidulans. J. Bact. 96, 1208–1213.CrossRefGoogle ScholarPubMed