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Synthesis and Characterization of PVA-HA-Silk Composite Hydrogel by Orthogonal Experiment

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Abstract

PVA-HA-Silk composite hydrogel was synthesized with polyvinyl alcohol (PVA), nano-hydroxyapatite (HA) and natural silk by using the method of repeated freezing and thawing. A series of tests were performed to study water content, stress relaxation behavior, elastic modulus, and creep characteristics of PVA-HA-Silk composite hydrogel. Orthogonal experimental design method was used to analyze the influence degree of PVA, HA and silk (three kinds of raw materials) on mechanical properties and water content of the PVA-HA-Silk composite hydrogel to select the best material ratio according to their overall performance. The results demonstrate that the mass percentage of P VA has the greatest impact on the water content, followed by HA and silk. Compression stress-strain variation of PVA-HA-Silk composite hydrogel presents a nonlinear relationship, which proves that it is a typical viscoelastic material. Comparing the mechanical properties of 16 formulas, the formula of PVA-HA-silk composite hydrogel with mass percentage of PVA 15%, HA 2.0% and silk 1.0% is the best.

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References

  1. Suciu A N, Iwatsubo T, Matsuda M, Nishino T. Wear characteristics of a novel bearing system for artificial knee joint. JSME International Journal Series C, 2004, 47, 209–217.

    Article  Google Scholar 

  2. Suciu A N, Iwatsubo T, Matsuda M, Nishino T. A study upon durability of the artificial knee joint with P VA hydrogel cartilage. JSME International Journal Series C, 2004, 47, 199–208.

    Article  Google Scholar 

  3. Oka M, Cha W I, Hyon S H, Ikeuchi K, Nakamura T. Wear-resistant properties of PVA-Hydrogel. Biomechanical Research, 1995, 16, 351–355.

    Google Scholar 

  4. Katta J K, Marcolongo M S, Lowrnan A M, Mansmann K A. Friction and wear characteristics of PVA/PVP hydrogels as synthetic articular cartilage. Proceedings of the IEEE 30th Annual Northeast Bioengineering Conference, Springfield, MA, USA, 2004, 142–143.

    Google Scholar 

  5. Warashina H, Sakano S, Kitamura S, Yamauchi K, Yamaguchi J, Ishiguro N, Hasegawa Y. Biological reaction to alumina, zirconia, titanium and polyethylene particles implanted onto murine calvaria. Biomaterials, 2003, 24, 3655–3661.

    Article  Google Scholar 

  6. Zheng Y D, Wang Y J, Chen X F, Liu Q, Wu G. Characterization and properties of poly(vinyl alcohol) /hydroxylapatite hydrogels prepared by compound in situ with sol-gel method. Chemical Journal of Chinese Universities, 2005, 26, 1732–1734. (in Chinese)

    Google Scholar 

  7. Xu F L, Li Y B, Li J D, Mo Y H. Swelling properties of nano-hydroxyaptite/polyvinyl alcohol hydrogel composite. Journal of Materials Engineering, 2005, 50, 15–18. (in Chinese)

    Google Scholar 

  8. Kobayashi H, Kato M, Taguchi T, Ikoma T, Miyashita H, Shimmura S, Tsubota K, Tanaka J. Collagen immobilized PVA hydrogel-hydroxyapatite composites prepared by kneading methods as a material for peripheral cuff of artificial cornea. Materials Science and Engineering C, 2004, 24, 729–735.

    Article  Google Scholar 

  9. Qi M, Gu Y, Sakata N, Kim D, Shirouzu Y, Yamamoto C, Hiura A, Sumi S, Inoue K. PVA hydrogel sheet macroen-capsulation for the bioartificial pancreas. Biomaterials, 2004, 25, 5885–5892.

    Article  Google Scholar 

  10. Bajpai A K, Vishwakarma N. Adsorption of polyvinylalco-hol onto Fuller’s earth surfaces. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2003, 220, 117–130.

    Article  Google Scholar 

  11. Zhang Y Z, Yin G B, Xu G. Study of structure and property of PVA/Glutin blend membranes. China Plastics Industry, 2004, 32, 34–36. (in Chinese)

    Google Scholar 

  12. Yang B C. The structure and physical property of PVA/Silk glue composite hydrogel. Silk Textile Technology Overseas, 1999, 3, 13–18. (in Chinese)

    Google Scholar 

  13. He Z Q. The jelly spinning manufacturing method of PVA/Silk glue admixture and its structure and physical Property. Silk Textile Technology Overseas, 2001, 5, 14–37. (in Chinese)

    Google Scholar 

  14. LV J. The structure and the biologic spinning process of natural silk and nephila silk. Advanced Textile Technology, 2004, 12, 40–42. (in Chinese)

    Google Scholar 

  15. Xu F L, Li Y B, Wang X J, Zuo Y, Han J. Preparation and characterization of nano-hydroxyapatite/polyvinyl alcohol biocomposites. Journal of Functional Materials, 2004, 35, 509–512. (in Chinese)

    Google Scholar 

  16. Willcox P J, Howie D W, Jr, Schmidt-Rohr K, Hoagland D A, Gido S P, Pudjijanto S, Kleiner L W, Venkatraman S. Microstructure of poly (vinyl-alcohol) hydrogels produced by freeze/thaw cycling. Journal of Polymer Science Part B: Polymer Physics, 1999, 37, 3438–3454.

    Article  Google Scholar 

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Correspondence to Dekun Zhang.

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Zhang, D., Chen, K., Wu, L. et al. Synthesis and Characterization of PVA-HA-Silk Composite Hydrogel by Orthogonal Experiment. J Bionic Eng 9, 234–242 (2012). https://doi.org/10.1016/S1672-6529(11)60116-9

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