Elsevier

The Ocular Surface

Volume 3, Issue 4, Supplement, October 2005, Pages S-169-S-172
The Ocular Surface

Cellular Mediators
Corneal Antigen Presentation: Molecular Regulation and Functional Implications

https://doi.org/10.1016/S1542-0124(12)70248-3Get rights and content

Abstract

Presentation of corneal antigens for induction of adaptive immune responses is mediated by corneal antigen-presenting cells (APC), including those that infiltrate the cornea in response to inflammatory stimuli and, to a lesser extent, those that reside in the cornea and up-regulate activation markers in response to inflammation. Significant progress has been made in the last decade in dissecting the molecular mechanisms that mediate APC infiltration into the cornea. However, it has recently been determined that exit of APC out of the cornea is critical for induction of T cells that normally reside outside of the cornea in lymphoid reservoirs. Much less is understood about the molecular regulation of APC egress from the cornea, but our laboratory has recently discovered that APC access to afferent lymphatics and draining lymph nodes requires signaling mediated by VEGFR-3. We describe herein the functional implication of APC trafficking and the prospects for novel immunomodulatory strategies based on regulating APC migration.

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Cited by (0)

Supported by NIH- EY RO1 012963.

The author has no proprietary interest in any product or concept discussed in this article.

Research was conducted in compliance with the ARVO Statement for the Use of Animals in Ophthalmic and Visual Research.

Abbreviations are printed in boldface where they first appear with their definitions.

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