Extravascular transport in normal and tumor tissues
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Factors affecting peptide and protein absorption, metabolism, and excretion
2023, Peptide and Protein Drug Delivery Using PolysaccharidesDual-layer detector spectral CT—a new supplementary method for preoperative evaluation of glioma
2021, European Journal of RadiologyCitation Excerpt :The grade of glioma is related to the microvascular proliferation, nuclear atypia, and mitosis in the tumor [28,29]. In HGG, substantial hyperplasia of anomalous cells can be observed, resulting in destruction of the blood–brain barrier, neovascularization, and an incomplete basement membrane of the tumor neovasculature, which in turns leads to augmentation of microvascular permeability [30,31]. The degree of CT enhancement can reflect the blood supply of the glioma, and we found that IC has a significant positive correlation with the degree of CT enhancement, but IC was more effective in predicting HGG.
Pharmacological considerations for predicting PK/PD at the site of action for therapeutic proteins
2016, Drug Discovery Today: TechnologiesCitation Excerpt :One tissue of special interest is tumor, which is generally highly vascularized, but the tumor vascularization is heterogeneous and can have large necrosis area with poor vascularization [18,19]. The permeability of blood capillaries in tumor is also high, but it is coupled with elevated interstitial pressure due to impaired lymph drainage [18,19]. Given the regional poor vascularization within large solid tumor, the diffusion distance for a drug molecule to reach its target can be much longer in tumor than that in normal tissues [19].
Scanning acoustic microscopy—A novel noninvasive method to determine tumor interstitial fluid pressure in a xenograft tumor model
2016, Translational OncologyCitation Excerpt :Elevated tumor interstitial fluid pressure (TIFP), as already shown in the early works of Young et al. in the 1950s, has been identified as a major barrier for transmigration of larger molecules into the interior of solid tumors [1]. TIFP is outwardly directed and hampers mainly the transport of big molecules as they are dependent on convectional flow rather than diffusional effects [2–4]. Moreover, a heightened TIFP not only has significant effects on molecular transport but also plays a role in inducing mechanical stress on the tumor capsule, thereby triggering cell proliferation; in turn, the lowering of TIFP accounts for beneficial effects on tumor progression [5,6].
Mapping of vascular ZIP codes by phage display
2012, Methods in EnzymologyCitation Excerpt :Abnormal features of tumor vasculature include large and variable intervascular distances, complex and tortuous branching patterns, lack of lymphatic vessel drainage, and irregular vascular phenotypes related to immaturity, angiogenic capacity, size, perfusion, and permeability (Carmeliet and Jain, 2000). Differences in anatomy, structure, and functional status of blood vessels are mirrored in the molecular diversity of vascular endothelial cells, including in the luminal side that is readily accessible to circulating probes (Allen and Cullis, 2004; Jain and Gerlowski, 1986; Ruoslahti, 2002). These systemically accessible receptors, vascular ZIP codes, can be used for synaphic (affinity-based) targeting using ligands such as peptides, antibodies, and aptamers for selective delivery of diagnostic and therapeutic cargo (Ruoslahti, 2002, 2004; Ruoslahti et al., 2010).