Current Biology
Volume 12, Issue 21, 29 October 2002, Pages R725-R727
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Immunoglobulin Genes: Generating Diversity with AID and UNG

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Abstract

Somatic hypermutation and switch recombination of immunoglobulin genes require the activity of the activation-induced deaminase, AID. Recent studies of mice deficient for the uracil-DNA glycosylase UNG, which removes U from DNA, suggest that AID catalyses the deamination of dC to dU during antibody diversification.

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