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Associations between cortical slow potentials and clinical rating scales in panic disorder: a 1.5- year follow-up study

Published online by Cambridge University Press:  16 April 2020

W. Dengler ,
G. Wiedemann  and
P. Pauli
W. Dengler
Affiliation:
Department of Psychiatry and Psychotherapy
G. Wiedemann
Affiliation:
Department of Psychiatry and Psychotherapy
P. Pauli
Affiliation:
Institute of Medical Psychology and Behavioural Neurobiology, University of Tübingen, Osianderstr. 24, D-72076Tübingen, Germany
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Summary

In a previous study of 15 panic patients, we demonstrated that body-related (somatic) word stimuli elicited an enhanced positive cortical slow wave compared to non-somatic word stimuli. Healthy controls did not show this difference. The present paper reports on psychometric ratings in relation to cortical slow waves in these patients. Patients were clinically reexamined after about 1.5 years. Although no significant correlations between neurophysiology and psychometric measures could be found at the onset of the study, there was a significant correlation between improvement over the follow-up period and neurophysiology. A decline in the Hamilton Anxiety Scale (HAMA), which proved to be the best estimate for improvement, was associated with the relative magnitude of the positive slow wave elicited by somatic stimuli. Our findings support cognitive models of panic disorder, which stress that abnormal processing of bodily symptoms is relevant for the development and/or maintenance of the disorder.

Keywords

clinical coursecortical slow wavesevent-related potentialpanic disorderpsychopathologyrating scales
Type
Original article
Information
European Psychiatry , Volume 14 , Issue 7 , November 1999 , pp. 399 - 404
Copyright
Copyright © European Psychiatric Association 1999

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