Abstract
The purpose of this study was to examine the relationship between platelet 5-HT2A receptor binding and aggressive behavior. 125I-LSD Bmax and Kd values were measured for 22 subjects meeting DMS-III-R criteria for one or more personality disorders and 12 healthy volunteer subjects. Aggression and impulsivity were assessed using the Buss-Durkee Hostility Inventory (BDHI) Assault scale, Life History of Aggression (LHA) scale, and the Barratt-11 Impulsiveness scale (BIS-11). Bmax and Kd values did not differ between personality disordered subjects and healthy volunteers. However, both Bmax and Kd values correlated positively with BDHI Assault scores in personality-disordered subjects but not in healthy volunteer subjects. These results suggest that assaultiveness in personality-disordered subjects may covary with increasing numbers, but decreasing affinity, of platelet 5-HT2A receptor sites labeled by 125I-LSD.
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Coccaro, E., Kavoussi, R., Sheline, Y. et al. Impulsive Aggression in Personality Disorder Correlates with Platelet 5-HT2A Receptor Binding. Neuropsychopharmacol 16, 211–216 (1997). https://doi.org/10.1016/S0893-133X(96)00194-7
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DOI: https://doi.org/10.1016/S0893-133X(96)00194-7
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