Determination of ofloxacin in human aqueous humour by high-performance liquid chromatography with fluorescence detection
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Cited by (45)
Analysis of pharmaceuticals and small molecules in aqueous humor
2018, Journal of Pharmaceutical and Biomedical AnalysisCitation Excerpt :Endophthalmitis treatment or preoperative prevention usually include vancomycin to cover gram-positive organisms, and a cephalosporin (e.g. ceftazidime) or an aminoglycoside (e.g. amikacin) to cover gram-negative bacteria [42–44]. Analysis of research articles qualified for this review showed, that determination of antibiotics by separation techniques was performed mainly on human [41,46–62] and rabbit [10,39,63–71], but also on horse [72], dog [73], bovine [74], monkey [10], and hen [75,76] AH samples. Similarly to IOP-lowering drugs, in case of antibiotics liquid chromatography with MS [10,49,50,53,56,58–60,63,67–69,71,73,75,76] or UV [39,46,47,54,55,57,62,65,72,74] detection was the most often used.
Simultaneous quantification of gatifloxacin, moxifloxacin, and besifloxacin concentrations in cornea and aqueous humor by LC-QTOF/MS after topical ocular dosing
2017, Journal of Pharmacological and Toxicological MethodsSimultaneous determination of moxifloxacin and ofloxacin in physiological fluids using high performance liquid chromatography with ultraviolet detection
2016, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesCitation Excerpt :Moxifloxacin was appropriately separated applying this method in standard mixtures, spiked plasma and aqueous humor samples as shown in Fig. 2. While ofloxacin was separated in standard mixture and spiked plasma samples while in aqueous humor ofloxacin gave interfering peaks at low concentrations, as reported earlier irrespective of its concentration [33] and at high concentrations the interfering peaks were separated to some extent from the drug. Various experimental parameters were optimized to select optimum stationary phase, mobile phase, mobile phase flow rate, internal standard, detector’s wavelength and column oven temperature.
Study on a host-guest interaction of hydroxypropyl-β-cyclodextrin with ofloxacin
2015, Journal of Molecular LiquidsA dual amplified electrochemical immunosensor for ofloxacin: Polypyrrole film-Au nanocluster as the matrix and multi-enzyme-antibody functionalized gold nanorod as the label
2013, Electrochimica ActaCitation Excerpt :However, the remain of these drugs in various foods of animal presents a potential danger such as toxic effect, resistant strain of bacteria, allergic hypersensitivity reaction, etc., which is harmful to human health especially to children or adolescents during the growth phase, and pregnancy or breast-feeding mothers [1,3]. Over years, different techniques such as spectrophotometry [3], HPLC [4], molecularly imprinted solid-phase extraction-LC [5], capillary electrophoresis [6], chemiluminescence [7], spectrofluorimetry [8] and microbiological assay [9] have been developed for the detection of OFL. These methods are well-proven and widely accepted; however, they are often viewed as laborious and time intensive in sample pretreatment.