Distinct ATP-activated currents in different types of neurons dissociated from rat dorsal root ganglion
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Acknowledgements
We thank Ms. Ke-Ming Xiong for preparation of figures.
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Cited by (42)
Phenotypes of ATP-activated current associated with their genotypes of P2X1-6 subunits in neurons innervating tooth-pulp
2015, Biochemical and Biophysical Research CommunicationsCitation Excerpt :In situ hybridization and immunohistochemical studies, however, revealed that of the cloned P2X receptor subunits, six (P2X1-P2X6) were expressed in sensory (including TG) neurons [8,9,10,12,13], thus raising the possibility that the native channels, including the channels expressed in nociceptive neurons, may be heteromultimers with diverse composition. Indeed, it has been reported that extracellular ATP can evoke different types of ion current, differing in a number of characteristics, such as current–voltage relationships, agonist and antagonist selectivities, modulation by endogenous agents, and desensitization rate, in nodose ganglion neurons [14,15,16], dorsal root ganglion neurons [17,18,19,20,21], and in TG neurons [3,4,10]. The molecular basis for the different types of ATP-activated current in different types of neuronal preparations, including nociceptive neurons, has not been established.
Effect of emodin on neuropathic pain transmission mediated by P2X2/3 receptor of primary sensory neurons
2011, Brain Research Bulletin