Acetyl-l-carnitine shows neuroprotective and neurotrophic activity in primary culture of rat embryo motoneurons
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Acknowledgements
P.B. is recipient of ‘Fondazione M. Monzino’ fellowship. Authors thanks Dr Stefania Casavecchia for her positive contribution.
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2017, Journal of Cranio-Maxillofacial SurgeryCitation Excerpt :ALCAR can pass the blood–brain barrier using the cation carnitine transporter (OCTN2) and plays a key role in the oxidation of free fatty acids (Smeland et al., 2012). Studies have reported that all the neuroprotective effects of ALCAR occur through an increase in intracellular neurotrophic pathways or cholinergic neurotransmission (Bigini et al., 2002; Ori et al., 2002). Recovery of peripheral nerve injury is possible using neuroprotective agents (Cheng et al., 2013).
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2014, International Journal of SurgeryCitation Excerpt :Recording wet muscle weight is a previously utilized alternative for motor target organ reinnervation [34–37]. In-vitro evidence suggests that ALC treatment improves the motor neuron activity, possibly acting as a neurotrophic factor [38], while evidence has been presented that suggests ALC may enhance functional muscle recovery in terms of attenuation of muscle atrophy, a reduction of foot drop, and increased toe spread [14]. Nerve conduction measurement is a direct evidence for the study of nerve transmission [39].
Acetyl-l-carnitine increases nerve regeneration and target organ reinnervation - a morphological study
2010, Journal of Plastic, Reconstructive and Aesthetic SurgeryCitation Excerpt :Recording wet muscle weight is a previously utilised proxy for motor target organ reinnervation.43,44,52,53 In-vitro evidence suggests that ALCAR treatment improves the motor neuron activity, possibly acting as a neurotrophic factor,54 while evidence has been presented that suggests ALCAR may enhance functional muscle recovery in terms of attenuation of muscle atrophy, a reduction of foot drop, and increased toe spread.32 Others have demonstrated improved endoneurial perfusion associated with improved motor nerve conduction velocity in a diabetic model.55
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