Communication Brèves

Pancréatite aiguë induite par la cimétidineCimetidine-induced acute pancreatitis

This chapter discusses gastrointestinal drugs and elaborates on antacids. It can reduce the absorption of many drugs, though not always to a clinically significant extent. Norfloxacin is a recent addition to this list. The chapter describes antacids such as sodium bicarbonate and aluminium hydroxide and explains their interactions with other drugs. There is also a description of antiemetics such as aliprazide, clebopride, metoclopramide, with their effects on the nervous system, cardiovascular, hematological, and overdosage effects. The chapter also elaborates antisecretory drugs and histamine H₂-antagonists. The advent of newer H2-antagonists does not so far appear to have extended the range of their usefulness or to have provided notably safer products. As in the case of some older drug families, such as the non-steroidal anti-inflammatory agents, the latest comer to the field is usually proclaimed to be safer simpler because it has not yet had time to exhibit the adverse effects typical of the group. It elaborates the risk situations of H₂-antagonists. Drugs like cimetidine, famotidine, nizatidine, ranitidine, their effects on nervous systems, hematological effects, effects on Liver, gastrointestinal effects, skin and appandages, have been discussed.