Editorial
In vitro radiosensitivity and normal tissue damage

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Cited by (19)

  • Individual Radiosensitivity Measured With Lymphocytes May Predict the Risk of Acute Reaction After Radiotherapy

    2008, International Journal of Radiation Oncology Biology Physics
    Citation Excerpt :

    The latter applies especially to tumor entities for which dose escalation is possible, such as those of the prostate, head and neck, and lung. It was calculated that such an individualization of radiotherapy might improve the overall success rate by more than 20% (13–16). The association between individual radiosensitivity and the risk of acute effects after radiotherapy appears to be less evident, with some reports showing a clear association but also others showing no obvious correlation (17–31).

  • Clonogenic survival and cytokinesis-blocked binucleation of skin fibroblasts and normal tissue complications in soft tissue sarcoma patients treated with preoperative radiotherapy

    2004, Radiotherapy and Oncology
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    Some studies suggest a trend between in vitro endpoints and the clinical reaction of patients to radiotherapy [3,8,45], while others have failed to establish this link [7,15,16,54]. Despite a significant investment into these predictive assays, their potential use in the clinic remains questionable [9,44,52]. The reasons for the minimal success in attempts to use in vitro cell survival and DNA damage responses after radiation exposure to predict clinical radiation reactions in patients remain unclear, but is likely related to the fact that cell survival and DNA damage repair are only two of numerous factors influencing radiation-induced normal tissue responses.

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