Chondrocyte-seeded hydroxyapatite for repair of large articular cartilage defects. A pilot study in the goat
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Instabilities induced by mechanical loading determine the viability of chondrocytes grown on porous scaffolds
2023, Journal of BiomechanicsAnalysis of the mechanical effects of defect shape on damage evolution of articular cartilage under rolling load
2018, Materials Science and Engineering CCitation Excerpt :Gratz et al. [15] found that the slip deformation of a notch with an 80° trapezoidal cross section was larger than that of a 100° trapezoidal cross section in full thickness cartilage under compressive loading. The literature also confirmed that the repair of cartilage with a 100° trapezoidal cross section defect, used by van Susante et al. [44], was better than cartilage with an 80° trapezoidal section, as used by Raub et al. [45]. We can infer that damage evolution velocity of cartilage with a rectangular cross-sectional defect is the slowest in our results, and a gap with a cylindrical shape is optimal in cartilage repair.
Elastomeric biomaterials for tissue engineering
2013, Progress in Polymer ScienceCitation Excerpt :The fibrin clot structure and composition, concentration of fibrinogen and protein factor XIII (which mediates crosslinking) considerably influence the elastic modulus and tensile strength of fibrin clots [504–507]. The modulus of fibrin was reported to be ∼50 Pa [508], and insufficient mechanical support was reported to be the main drawback of fibrin for its application in articular cartilage repair strategies tested in animal models [509]. Fibrin is subject to enzyme-mediated hydrolytic degradation, known as fibrinolysis both in vivo and in vitro.
Application of albumin-grafted scaffolds to promote neocartilage formation
2012, Colloids and Surfaces B: BiointerfacesCitation Excerpt :Thus, the pore surface of scaffolds is usually modified by bioactive motif. For example, human fibronectin, hydroxyapatite, polyethyleneimine, heparin, chondroitin sulfate, and laminin-derived peptide have been coated on the material surfaces for culturing chondrocytes [18–28]. Human serum albumin comprises 585 amino acid residues with a molecular weight of 66.5 kDa and contains 35 cysteinyl residues with one sulfhydryl group and 17 disulfide bonds [29].
Construction of osteochondral-like tissue graft combining β-tricalcium phosphate block and scaffold-free centrifuged chondrocyte cell sheet
2011, Journal of Orthopaedic Science