CARNITINE DEFICIENCY INDUCED DURING INTERMITTENT HÆMODIALYSIS FOR RENAL FAILURE

doi:10.1016/S0140-6736(78)90422-1

The Lancet

Volume 311, Issue 8056, 21 January 1978, Pages 126-128

https://doi.org/10.1016/S0140-6736(78)90422-1 Get rights and content

Abstract

Carnitine concentration was measured in plasma, muscle, and dialysate before and after hæmodialysis in patients with renal failure and in plasma and muscle of healthy controls. In eight of the nine patients carnitine concentration in muscle after hæmodialysis was only 10% of the concentration in controls. Plasma-carnitine varied in patients before dialysis and in all of them was reduced by dialysis. The loss of carnitine into the dialysate (190-2100 μmol/treatment) greatly exceeded the normal loss in urine for most of patients, and was only partly compensated for. In some patients normal or high plasma-carnitine and low concentrations in muscle indicated that the carnitine-concentrating mechanisms in the muscle cell had failed. The reduction in carnitine will interfere seriously with normal cellular functions and this may help to explain the clinical syndrome of cardiomyopathy and cardiac failure which has been observed in some patients treated for a long time with intermittent hæmodialysis.

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Preliminary CommunicationsCARNITINE DEFICIENCY INDUCED DURING INTERMITTENT HÆMODIALYSIS FOR RENAL FAILURE

Abstract

Clinica. chim. Acta

Clinica. chim. Acta

Biochim. biophys. Acta

Clinica. chim. Acta

Br. med. Bull.

Kidney Int.

Preliminary Communications
CARNITINE DEFICIENCY INDUCED DURING INTERMITTENT HÆMODIALYSIS FOR RENAL FAILURE