CommentMetabolic phenotyping for monitoring surgical patients
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Baicalein attenuates the neuroinflammation in LPS-activated BV-2 microglial cells through suppression of pro-inflammatory cytokines, COX2/NF-κB expressions and regulation of metabolic abnormality
2020, International ImmunopharmacologyCitation Excerpt :Metabolomics is a bioanalytical approach for discovery of the metabolic changes under physiological and pathological conditions [15], which is used for discovery of disease biomarkers and elucidation of drug actions [16]. Nuclear magnetic resonance (NMR) metabolomics is widely used in drug research based on its untargeted, reproducible, non-destructive and unbiased advantages [17–19]. Several ongoing studies have demonstrated that neuroinflammation could indeed cause metabolic changes by using metabolomics approach [20–22].
A Unified Conceptual Framework for Metabolic Phenotyping in Diagnosis and Prognosis
2019, Trends in Pharmacological SciencesCitation Excerpt :However, the rewards in terms of optimized treatment of patients, reduced morbidity and mortality, and improved health economics make this a worthwhile challenge. Ultimately, systems medicine must be practical in the real world and deliver clinically actionable outcomes: the concept of patient journey phenotyping [63] implemented using metabolic tools will greatly assist this. One excellent, recent, surgical implementation of metabolic profiling is that of the i-knife which uses MS to analyze compounds present in the smoke created by surgical cauterization of patient tissue.
Perioperative Genomics
2018, Genomic and Precision Medicine: Cardiovascular Disease: Third EditionMetabolomic study of the intervention effects of Shuihonghuazi Formula, a Traditional Chinese Medicinal formulae, on hepatocellular carcinoma (HCC) rats using performance HPLC/ESI-TOF-MS
2017, Journal of EthnopharmacologyCitation Excerpt :It has recently demonstrated significant potential in many fields such as cancer, nutrition, toxicology, comparing different growth stages, diabetes, disease diagnosis and natural product discovery (Wang et al., 2011; Bruce, 2011; Zeisel et al., 2005; Wang et al., 2009; Dutta et al., 2012; Tan et al., 2012b; Hou et al., 2012). One area of considerable interests in the field of metabolomics is that of drug discovery and development, whereby metabolic profiling of biofluids and tissues can provide a global view of abundance changes of endogenous metabolites in monitoring cellular responses to perturbations of drug treatment (Chan et al., 2011; Kinross et al., 2011). Metabolomics, as a systemic approach, it adopts a ‘top-down’ strategy to reflect the function of organisms from terminal symptoms of metabolic network and understand drug-target networks caused by interventions in holistic context (Holmes et al., 2008).
Metabolomic analysis of glycerophospholipid signatures of inflammation treated with non-steroidal anti-inflammatory drugs-induced-RAW264.7 cells using <sup>1</sup>H NMR and U-HPLC/Q-TOF-MS
2016, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesA multiplexed targeted assay for high-throughput quantitative analysis of serum methylamines by ultra performance liquid chromatography coupled to high resolution mass spectrometry
2016, Archives of Biochemistry and Biophysics