Chronic fatigue syndrome: Identification of distinct subgroups on the basis of allergy and psychologic variables☆,☆☆,★,★★
Section snippets
Center model
The data collected for this study were generated as part of a study examining possible pathophysiologic mechanisms of the production of CFS.
Subjects
Studies were performed on age- and sex-matched normal subjects (n = 11) and subjects with CFS (n = 18). CFS was defined according to the original Centers for Disease Control and Prevention definition,14 which requires a history of debilitating idiopathic fatigue producing a greater than 50% reduction in activity from the premorbid state. To optimize
RESULTS
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ELISA
We investigated activation of the proinflammatory cytokines TNF-α, IFN-α, and IL-1β in PBMCs in subjects with CFS. As has been previously reported,1, 2, 3, 4, 5 most (15 of 18) of the subjects with CFS were atopic as demonstrated by skin test reactivity. Most of the depressed patients were also atopic (7 of 10 on whom skin testing could be performed).21 Concentrations of cell-associated cytokines were assayed by means of ELISA, and data are normalized to cell (PBMC) number. Individual data
RT-PCR
In addition to intracellular immunoreactive protein, we identified cytokine involvement in CFS as mRNA transcripts in the PBMCs of subjects with CFS. Data were quantified by means of densitometric analyses of cytokine transcript product that was normalized to the level of expression of β-actin as described. Representative data obtained by using nested 32P-labeled probes for TNF-α are displayed in Fig. 5.
DISCUSSION
We investigated the role of allergic inflammation in the pathophysiology of CFS. This was based on the surprisingly high association of CFS with allergy (10% to 20% of the general population is atopic compared with 55% to 80% of subjects with CSF)1, 2, 3, 4, 5 and the association of allergic conditions such as allergic rhinitis with fatigue. Allergies are the only consistent immune abnormality present in CFS and suggest a role for allergic inflammation in the development of CFS. In one of the
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2019, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Of the remaining studies recruiting adults, the average age ranged from 34 (CFS) and 30 (controls) reported by Lloyd et al. (1994) to 50 (CFS) and 53 (controls) by Broderick et al., 2010, with most studies reporting an average age between 40 and 50. Most studies utilised the CDC diagnostic criteria for CFS (Bennett et al., 1997; Borish et al., 1998; Buchwald et al., 1997; Cannon et al., 1999; Chao et al., 1991; Cheney et al., 1989; Giloteaux et al., 2016; Hardcastle et al., 2015; Jammes et al., 2009; Kennedy et al., 2004; Lattie et al., 2012; Macdonald et al., 1996; Maes et al., 2012; Montoya et al., 2017; Nakamura et al., 2010, 2013; Nater et al., 2008; Neu et al., 2014; Peterson et al., 1994; Raison et al., 2009; Robinson et al., 2010; Scully et al., 2010; Smylie et al., 2013; Spence et al., 2008; Straus et al., 1989; Sulheim et al., 2014; White et al., 2004, 2010; Wyller et al., 2015), while others used the ICD criteria (Broderick et al., 2010, 2013) or the Canadian criteria (Lidbury et al., 2017) and some used multiple diagnostic criteria (Ford et al., 2016; Hornig et al., 2017; Khaiboullina et al., 2015; Landi et al., 2016; Nagy-Szakal et al., 2017; Nakatomi et al., 2014; Russell et al., 2016). Appendix B contains more information regarding the quality assessment.
Anti-food IgG assays: Methods and clinical relevance of results. Position of the biology task force of the French society of allergy
2018, Revue Francaise d'AllergologieChronic Fatigue Syndrome
2017, Principles and Practice of Pediatric Infectious Diseases
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From the Departments of aMedicine and bPediatrics, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver; and cthe Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle.
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Supported by National Institutes of Health grant AI32244 and General Clinical Research Center grant MO1 RR00051.
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Reprint requests: James F. Jones, MD, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, University of Colorado Health Sciences Center, Denver, CO 80206.
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