Thiol-based antioxidants

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The thiol redox status of intracellular and extracellular compartments is critical in the determination of protein structure, regulation of enzyme activity, and control of transcription factor activity and binding. Thiol antioxidants act through a variety of mechanisms: (1) as the components of the general thiol/disulfide redox buffer, (2) as metal chelators, (3) as radical quenchers, (4) as substrates for specific redox reactions (GSH), and (5) as specific reductants of individual protein disulfate bonds (thioredoxin). The composition and redox status of the available thiols in a given compartment is highly variable and must play a part in determining the metabolic activity of each compartment. It is generally beneficial to increase the availability of specific antioxidants under conditions of oxidant stress. Cells have devised a number of mechanisms to promote increased intracellular levels of thiols, such as GSH and thioredoxin, in response to a wide variety of stresses. Exogenous thiols have been used successfully to increase cell and tissue thiol levels in cell cultures, in animal models, and in humans.

References (180)

  • DiMascioP. et al.

    Am. J. Clin. Nutr.

    (1991)
  • AnbarM. et al.

    Int. J. Appl. Radiat. Isot.

    (1967)
  • GilbertH.F.

    Methods Enzymol.

    (1995)
  • LashL.H. et al.

    ARch. Biochem. Biophys.

    (1985)
  • BannaiS.

    Biochim. Biophys. acta

    (1984)
  • HoggN. et al.

    FEBS Lett.

    (1996)
  • ScorzaG. et al.

    Free Radic. Biol. Med.

    (1997)
  • GriffithO.W. et al.

    J. Biol. Chem.

    (1979)
  • AkerboomT.P.M. et al.

    FEBS Lett.

    (1982)
  • TaylorC.G. et al.

    Curr. Top. Cell. Regul.

    (1996)
  • MeredithM.J. et al.

    J. Biol. Chem.

    (1982)
  • MeredithM.J. et al.

    Biochem. Pharmacol.

    (1983)
  • SmithC.V. et al.

    Toxicol. Appl. Pharmacol.

    (1996)
  • Garcia-RuizC. et al.

    J. Biol. Chem.

    (1992)
  • EsworthyR.S. et al.

    Arch. Biochem. Biophys.

    (1993)
  • LashL.H. et al.

    J. Biol. Chem.

    (1984)
  • ButterworthM. et al.

    Biochem. Pharmacol.

    (1993)
  • DenekeS.M.

    Biochim. Biophys. Acta

    (1992)
  • BeattyP. et al.

    Biochem. Pharmacol.

    (1981)
  • HanD. et al.

    Biochem. Biophys. Res. Commun.

    (1995)
  • CotgreaveI.A. et al.

    Biochim. Biophys. acta

    (1994)
  • ChoiJ. et al.

    Biochem. Pharmacol.

    (1997)
  • BannaiS.

    J. Biol. Chem.

    (1984)
  • BannaiS. et al.

    Biochim. Biophys. Acta

    (1991)
  • SatoH. et al.

    J. Biol. Chem.

    (1999)
  • YamaguchiM. et al.

    Biochem. Biophys. Res. Commun.

    (1993)
  • SatoM. et al.

    Free Radic. Biol. Med.

    (1993)
  • BaumanJ.W. et al.

    Toxicol. Appl. Pharmacol.

    (1991)
  • FurstP. et al.

    Cell

    (1988)
  • AlboresA. et al.

    Chem. Biol. Interact

    (1992)
  • ChenC.L. et al.

    J. Inorg. Biochem.

    (1994)
  • HartB.A. et al.

    Environ. Res.

    (1989)
  • BaumanJ.W. et al.

    Toxicol. Appl. Pharmacol.

    (1992)
  • MinK.S. et al.

    Toxicol. Appl. Pharmacol.

    (1991)
  • ItanoY. et al.

    Neurosci. Lett.

    (1991)
  • AbelJ. et al.

    Toxicol. Lett.

    (1989)
  • OchiT. et al.

    Chem. Biol. Interact.

    (1989)
  • ThornalleyP. et al.

    Biochim. Biophys. Acta

    (1985)
  • SchwarzM.A. et al.

    J. Biol. Chem.

    (1994)
  • LiuX.D. et al.

    Methods

    (1997)
  • PackerL. et al.

    Free Radic. Biol. Med.

    (1995)
  • HandelmanG.J. et al.

    Biochem. Pharmacol.

    (1994)
  • PackerL. et al.

    Free Radic. Biol. Med.

    (1997)
  • HolmgrenA.

    Structure

    (1995)
  • HolmgrenA.

    J. Biol. Chem.

    (1989)
  • MitsuiA. et al.

    Biochem. Biophys. Res. Commun.

    (1992)
  • FloheL.
  • MeisterA. et al.

    Annu. Rev. Biochem.

    (1983)
  • GilbertH.F.

    Adv. Enzymol.

    (1990)
  • AnderssonA. et al.

    Clin. Chem.

    (1995)
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