New Methods & MaterialsHigh-resolution endoscopic imaging of the GI tract using optical coherence tomography☆,☆☆
Section snippets
PATIENTS AND METHODS
Patients scheduled for elective endoscopy (upper endoscopy, flexible sigmoidoscopy, and colonoscopy) were eligible for enrollment in the study. Patients were excluded for the following reasons: age under 18 years, those undergoing endoscopy on an emergency basis (e.g., acute GI bleeding), inability to give informed consent, or a contraindication to endoscopy (e.g., severe cardiopulmonary disease). Informed consent for both endoscopy and participation in the study were obtained from patients.
RESULTS
The following anatomic sites were studied in 38 patients: esophagus (21), stomach (12), duodenum (11), terminal ileum (4), colon (15), and rectum (9). A total of 72 sites were imaged. Endoscopic biopsies obtained at all sites were interpreted as normal.
The prototype OCT probe was found to be fully compatible with standard upper endoscopes, sigmoidoscopes, and colonoscopes. The probe, as presently designed, cannot be used with a side-viewing instrument with a catheter elevator. There were no
DISCUSSION
The prototype OCT system offered excellent high-resolution cross-sectional images in the esophagus. Depth of penetration and image quality in the stomach, duodenum, and to a lesser degree the colon were not as good as in the esophagus. These difference might be related to optical properties intrinsic to each organ. Another possible explanation is that the esophagus is relatively easy to scan inasmuch as the OCT probe aligns naturally in the desired perpendicular orientation for scanning.
DISCLOSURE STATEMENT
Authors M.V.S. and A.M.R. have proprietary interests in the OCT catheter probe.
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Supported by and performed in collaboration with the Olympus Optical Co., Ltd., Tokyo, Japan.
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Reprint requests: M. V. Sivak, Jr., MD, Division of Gastroenterology (Wearn 253), University Hospitals of Cleveland, 11100 Euclid Ave., Cleveland, OH 44106; fax: 216-844-7371.