Biochemical and Biophysical Research Communications
Growth hormone-dependent insulin-like growth factor (IGF) binding protein both inhibits and potentiates IGF-I-stimulated DNA synthesis in human skin fibroblasts
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Role of IGF Binding Proteins in Regulating Metabolism
2016, Trends in Endocrinology and MetabolismSingle nucleotide polymorphism in Egyptian cattle insulin-like growth factor binding protein-3 gene
2014, Journal of Genetic Engineering and BiotechnologyCitation Excerpt :On the other hand, twenty-six animals (56.52%) are genotyped as AC heterozygous patterns with 9 digested fragments whereas the allele frequencies for A and C allele are identical and equal 50% for each of them. As one of six related proteins that modify IGF bioactivity in complex [14,30,34], both inhibiting and enhancing effects of IGFBP3 on IGF-I action have been reported [6,8,9,23]. Therefore concentrations of IGFBPs are potential indicators of IGF-I status and may provide insight into an animal’s growth or carcass potential.
Attenuation of IGF-I receptor signaling inhibits serum-induced proliferation of prostate cancer cells
2011, Growth Hormone and IGF ResearchCitation Excerpt :Values are presented as the mean ± SEM. Since IGF-I is a known survival factor [4] that also stimulates cell cycling in many cell types [20–22], it is conceivable that IGF-I affects tumor growth via both mechanisms. To address the contribution of these mechanisms in the effects of IGF-I on the proliferation of Du145 cells, we assessed the effects of IGF-I on cell number, DNA synthesis and cell survival.
Functional modulation of IGF-binding protein-3 expression in melanoma
2010, Journal of Investigative DermatologyCitation Excerpt :IGFBP3 is one member of this family, and has been shown to inhibit cell proliferation in breast, lung and prostrate cancer cells, and in some cell lines to reduce tumor growth (Hwa et al., 1999). IGFBP3 is reported to be a growth suppressor by virtue of its effects on multiple pathways (De Mellow and Baxter, 1988; Valentinis et al., 1995). In the IGF receptor-dependent pathways, IGFBP3 binds to IGF-1, 2 and suppresses its growth signal (De Mellow and Baxter, 1988).