EditorialCutaneous vaccination – Protective immunization is just a skin-deep step away
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Cited by (8)
Epicutaneous immunization using synthetic virus-like particles efficiently boosts protective immunity to respiratory syncytial virus
2021, VaccineCitation Excerpt :Since the main indication of a prophylactic treatment against RSV would be young children and pregnant woman, non-invasive and safe vaccine approaches should be given paramount consideration. Skin has been unequivocally identified as a promising route for vaccination due to its richness in innate and adaptative immune effector cells [23,24]; however, for ease of application, most conventional injectable vaccines are still delivered into the subcutaneous space or into the muscle, thus bypassing the rich network of antigen presenting cells present in the skin. Several years ago, a novel epicutaneous delivery system was developed for food allergy treatment [25,26].
Epidermal micro-perforation potentiates the efficacy of epicutaneous vaccination
2019, Journal of Controlled ReleaseCitation Excerpt :Skin has long been recognized as an attractive route for the induction or the modulation of immune responses, i.e. vaccination or immunotherapy, based on its unique immunological features [1].
Application of water-soluble polyvinyl alcohol-based film patches on laser microporated skin facilitates intradermal macromolecule and nanoparticle delivery
2018, European Journal of Pharmaceutics and BiopharmaceuticsCitation Excerpt :During the past decades, the research and knowledge regarding the intradermal delivery of biologics and particularly vaccines has significantly increased [1,2].
Long-lived tissue resident HIV-1 specific memory CD8<sup>+</sup> T cells are generated by skin immunization with live virus vectored microneedle arrays
2017, Journal of Controlled ReleaseCitation Excerpt :Therefore, vaccination strategies that can in addition programme antigen experienced T cells to provide long term memory at the mucosal surfaces and respond rapidly to antigen re-encounter, would be of immense benefit in the development of effective vaccines against mucosally acquired pathogens, including HIV. The skin is an attractive target for vaccine delivery for ease of administration and as a consequence of the high density of antigen presenting cells localized in the epidermis and dermis that are accessible for acquisition of vaccine antigens [9–12]. Current vaccination strategies involve the use of intra-dermal needle injections as a system for vaccine delivery to this rich network of cutaneous antigen-presenting cells.
Rabies vaccination in dogs using a dissolving microneedle patch
2016, Journal of Controlled ReleaseCitation Excerpt :In a dissolving microneedle patch, an array of microneedles is attached to a backing such that it can be applied to the skin by hand like a bandage. After insertion into the skin, the microneedles dissolve in the skin within minutes, thereby delivering the vaccine contained in them and not generating sharps waste [26–36]. In a dissolving microneedle patch, the vaccine is encapsulated within the microneedles.