Elsevier

Urology

Volume 65, Issue 5, May 2005, Page 1001
Urology

Case report
Unilateral testicular mass in man with chronic myelomonocytic leukemia: Unusual presentation of chronic myelomonocytic leukemia sequela

https://doi.org/10.1016/j.urology.2004.11.041Get rights and content

Abstract

Extramedullary myeloid cell tumors are discrete tissue infiltrations by leukemic cells of myeloid lineage. They are more commonly associated with relapsing acute myelogenous leukemia but can occur in myeloproliferative/myelodysplastic leukemia, usually associated with disease acceleration. Although they can occur in any organ, reported testicular infiltration is rare. We describe the clinical presentation of an extramedullary myeloid cell tumor as a unilateral testicular mass in a man with known chronic myelomonocytic leukemia and its histologic diagnosis. To our knowledge, this manner of presentation is unique in this clinical context.

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Case report

A 79-year-old man presented to the uro-oncology clinic with a 5-week history of a left testicular mass. Two years previously, he had been diagnosed with chronic myelomonocytic leukemia on a bone marrow aspirate performed for investigation of recurrent epistaxis and thrombocytopenia. He also had a long-standing diagnosis of beta-thalassemia trait. On examination, he had a hard irregular mass arising in his left testis with no palpable lymphadenopathy or organomegaly.

Ultrasound examination of his

Comment

EMCTs are solid tumors composed of infiltrating cells of myeloid lineage.1 They are rarely associated with myelodysplastic/myeloproliferative disease, in which they usually herald the onset of blastic transformation.2 More commonly, they are associated with acute myelogenous leukemia, either as a first presentation or as a relapse after treatment. EMCTs can involve any organ, but preferentially occur in the skin, lymph nodes, gastrointestinal tract, and orbit.

Fewer than 12 cases of EMCT

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