Trends in Chemistry
SpotlightA Long-Sought Reactivity of a Sodium Hydride
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Acknowledgments
Financial support from the National Science Center, Poland (Grant OPUS 2019/35/B/ST4/02794 for B.F. and Grant PRELUDIUM 2018/29/N/ST5/01938 for P.J.C.) is gratefully acknowledged.
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Incorporation of germanium into amines via deoxygenative germylation of aromatic amides with hydrogermanes
2022, Cell Reports Physical ScienceCitation Excerpt :Due to the importance of amines in various areas and the significant germanium switch effect,1,2,3 the development of Ge–H insertion reactions of carbenes with N substitutes, preferably generated from simple and widely available precursors, is of considerable interest yet poses a nontrivial challenge for the chemistry community (Figures 1B–1Bii). The natural prevalence and ready synthetic accessibility of amides make them attractive precursors to α-functionalized amines, e.g., via deoxygenative functionalization of the amides.55,56,57,58,59,60,61 However, the inert nature of an amide, as a result of resonance stabilization, generally necessitates the use of harsh conditions and a tedious multi-step process.
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2021, Journal of Organic ChemistryMerging Electron Transfer Activation with 1,2-Metalate Migration: Deoxygenative Silylation of Amides
2023, Chinese Journal of Organic ChemistrySmI<inf>2</inf>/Sm-Arylboronic Esters Combination for the Reductive Arylation of Aromatic Tertiary Amides
2021, Chinese Journal of Organic ChemistryReductive Functionalization of Amides in Synthesis and for Modification of Bioactive Compounds
2021, Frontiers in Chemistry