Thoracic transplantationLung Transplantation in Patients With Cystic Fibrosis
Section snippets
Methods
This retrospective cohort study examined medical charts and a prospective databank of patients who underwent transplantation between 2000 and 2011 with follow-up through September 2012. We assessed all patients diagnosed with CF including our adult and pediatric populations. The study was approved by our ethics committee. We collected recipient pretransplant variables: age, gender, body mass index (BMI), blood type, diabetes, pancreatic exocrine failure, duration of disease, secondary pulmonary
Results
Between 2000 and 2011, we performed 150 lung transplantations for chronic obstructive pulmonary disease (COPD) (26.7%), CF (20%), pulmonary fibrosis (20%), bronchiectasis (17.3%), lymphangioleiomyomatosis (6%), primary pulmonary hypertension (2.7%), or other causes (7.3%). There were 102 bilateral (68%), 21 right single (14%), and 27 left single (18%) procedures. The 30 patients who underwent lung transplantation for CF showed a mean age of 27.4 ± 9.2 years with 2 younger than 18 years. There
Discussion
Lung transplantation is a well-known treatment for CF end-stage lung disease accounting for 16.8% of all cases worldwide according to the ISHLT registry.1 The first successful heart-lung and lung transplantations were performed in 1983 and 1987, respectively.2 Although the first lung transplantation in our institution was performed in 1990, only after 2000 did it become a more common surgery routinely performed in our hospital. Since then we have performed 150 transplantations with a
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Cited by (11)
Cystic Fibrosis Lung Transplant Recipients Have Suppressed Airway Interferon Responses during Pseudomonas Infection
2020, Cell Reports MedicineCitation Excerpt :Because the host sinotracheal tract is not replaced during lung transplantation, recolonization with PsA is common in CF lung transplant recipients.11 Nonetheless, CF recipients do better following lung transplantation than non-CF recipients in many, although not all, reports.6,12–16 Given the potentially favorable outcomes for CF recipients, we hypothesized that host or microbiome adaptations in CF patients attenuate immune responses to PsA that would otherwise result in CLAD.
Indications for lung resection surgery and lung transplant in South American children with cystic fibrosis
2018, Paediatric Respiratory ReviewsCitation Excerpt :The median survival of infected and uninfected patients was 3.3 years and 12.4 years, respectively [27]. Between August 2003 and August 2016, there were a total of 274 LTx, and 62 (22.6%) of these procedures were done on patients with CF, the second leading cause of all LTx in our center [30] and the first leading cause among pediatric recipients [31]. Fourteen LTx (22.5%) were performed in CF patients under the age of 18 years, in eight girls and six boys with a median age of 13.2 years (range: 8–18 years).
Long-term survival after lung transplantation among cystic fibrosis patients: Moving away from mere palliation
2016, Journal of Heart and Lung TransplantationRisk factors of wound infection after lung transplantation: a narrative review
2022, Journal of Thoracic DiseaseEvaluation of autonomic modulation of lung function and heart rate in children with cystic fibrosis
2021, Pediatric Pulmonology