LiverOutcomePsychological Risk Factors for Graft Rejection Among Liver Transplant Recipients
Section snippets
Methods
After ethical committee approval, 44 candidates listed for OLT were asked to participate in the study to undergo psychological evaluation before transplantation. Inclusion criteria were a stable clinical condition in an out-patient setting, a minimum of a secondary school education, and written informed consent. We excluded patients with fulminant hepatitis, psychotic disturbances, neurocognitive deficits, dementia, serious mental retardation (IQ <50), current alcohol or drug abuse, recent
Results
Table 1 shows the demographic and medical characteristics of patients who experienced various types of rejection. Patients suffering from versus free of acute graft rejection displayed a greater fear of repulsive animals score (10.2 ± 8.7 versus 5.1 ± 6.0; P < .05; Table 2). Obsessive behavior concerning hygiene (1.2 ± 1.2 versus 2.6 ± 1.6; P < .05) was lower among patients with versus without chronic graft rejection (Table 3). Analysis of variance Anova CBA 2.0 variables did not reveal any
Discussion
We prospectively demonstrated, for the first time, that fear for repulsive animals and neuroticism were associated with acute and chronic graft rejection, respectively. A higher fear for repulsive animals score was able to predict acute graft rejection episodes.It is well-known that pre-transplantation and posttransplantation psychological status affect the quality of life among posttransplant patients.11, 12
A relationship between hormone levels and immunomodulation is well known.15 Some
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Psychological graft-rejection: A need to understand the construct in transplant scenarios
2023, Asian Journal of PsychiatryPsychosocial treatment on psychological symptoms, adherence, and physiological function on transplanted patients: A systematic review and metanalysis
2022, Journal of Psychosomatic ResearchCitation Excerpt :Psychosocial interventions to the transplanted recipients could be important in order to achieve the reduction of psychosocial distress, and the improvement of personal functioning and the general perception of health [9,10]. Psychosocial interventions, that comprise interventions focused on psychological or social support, can be helpful in all transplantation stages enabling patients to better manage this extraordinarily stressful situation, as well as to promote and improve a good adherence in dialysis [11,12], to the medical cares, and to the adequate lifestyle indications [13,14]. Moreover, applying psychosocial interventions in all stages of the transplantation process (pre- and -post transplant) could allow to identify possible risk factors, and to prevent negative outcome of the surgery [3].
Perceived body image and distress after liver tansplantation in recipients
2021, Transplant ImmunologyEvaluation of the SIPAT instrument to assess psychosocial risk in heart transplant candidates: A retrospective single center study
2017, Heart and Lung: Journal of Acute and Critical CareCitation Excerpt :Furthermore, the need for psychosocial assessment is widely recognized by core professional agencies which establish best practices in heart transplantation.3,4 Published data suggest that there is an association between pre-transplant psychosocial risk and post-transplant outcomes.5–13 Common pre-transplant psychological variables associated with a greater hazard of post-transplant mortality include previous suicide attempts, poor adherence to medical recommendations, past history of substance abuse, current depressive disorders, psychosocial functioning, and social support.14–18
Utility of pretransplant psychological measures to predict posttransplant outcomes in liver transplant patients: A systematic review
2016, General Hospital PsychiatryCitation Excerpt :Two other studies found no significant relationship between pre-LT depression score and graft rejection [24–26]. As with the survival outcome, all four studies that examined pre-LT anxiety symptoms reported no association with graft rejection [22,24–26]. Depression before transplant predicted decreased general life satisfaction after transplant (beta =− 0.30, P = .01), whereas pre-LT anxiety predicted greater general life satisfaction after transplant (beta = 0.37, P = .01) in study by Goetzmann et al. [21].
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