Kidney preservation with IGL-1 solution: A preliminary report
Section snippets
Materials and methods
From June 27, 2003, until June 30, 2004, 119 cadaveric kidneys were retrieved and stored in IGL-1 solution. Among these 119 organs, 48 were locally transplanted while the other kidneys were exported to other French centers as a result of exchange activities within “Etablissement Français des Greffes” organization.
This first clinical study compares 37 IGL-1-preserved kidneys that were locally transplanted with 33 kidneys stored in UW solution and transplanted between August 27, 2002, and
Results
Figure 1 illustrates the evolution of serum creatinine during the first 15 postoperative days. Creatinine values were significantly lower among the IGL-1 group from 2 to 14 days after transplantation. At 1 month posttransplantation the serum creatinines were 124.72 mmol/L and 105.17 mmol/L in UW and IGL-1 kidneys (P = .030), although they were not significantly different at 3, 6, or 12 months.
Daily urinary output did not show any significant difference between the two groups. Compared to UW
Discussion
The present study sought to compare IGL-1 versus UW solution for protection of the kidney grafts against cold ischemic storage and reperfusion injuries. IGL-1 solution, which is characterized by high Na concentration and PEG 35 substitution for HES, was previously tested in an isolated perfused rat kidney model and in a pig kidney autotransplant model.7 The experimental studies demonstrated that the inversion of K+ and Na+ concentrations leads to an improved fractional sodium reabsorption and
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