Elsevier

Tetrahedron Letters

Volume 54, Issue 29, 17 July 2013, Pages 3892-3895
Tetrahedron Letters

Regioselective synthesis of pyrano[3,2-c]coumarins via Cu(II)-catalyzed tandem reaction

https://doi.org/10.1016/j.tetlet.2013.05.061Get rights and content

Abstract

Efficient synthesis of pyrano[3,2-c]coumarins has been achieved via copper(II) triflate catalyzed tandem reaction of 4-hydroxycoumarin with α,β-unsaturated carbonyl compounds in high yields. The catalytic reaction proceeded very smoothly under solvent-free conditions and showed high regioselectivity. The synthetic potential of this methodology was explored to 4-hydroxy-6-methyl-2-pyrone successfully.

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Acknowledgments

A.H. and A.M. acknowledge the financial support from DST, Govt. of India (Grant No. SR/S5/GC-05/2010). We are thankful to DST-FIST and UGC-SAP. A.K.B. thanks CSIR for his fellowship.

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