Elsevier

Tetrahedron Letters

Volume 52, Issue 44, 2 November 2011, Pages 5774-5776
Tetrahedron Letters

A novel one-pot domino reaction for the synthesis of 2-acetyl-3-(phenylamino)indolizine-1-carboxamide derivatives

https://doi.org/10.1016/j.tetlet.2011.08.118Get rights and content

Abstract

2-Acetyl-3-(phenylamino)indolizine-1-carboxamide derivatives were obtained via a one-pot domino reaction of alkyl or aryl isocyanides and pyridine-2-carbaldehyde in the presence of acetoacetanilide in toluene without any prior activation or modification.

Graphical abstract

2-Acetyl-3-(phenylamino)indolizine-1-carboxamide derivatives were obtained via a one-pot domino reaction of alkyl or aryl isocyanides and pyridine-2-carbaldehyde in the presence of acetoacetanilide in toluene without any prior activation or modification.

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Acknowledgments

We gratefully acknowledge financial support from the Research Council of the University of Sistan and Baluchestan.

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