Ibuprofenamide: a convenient method of synthesis by catalytic hydration of 2-(4-isobutylphenyl)propionitrile in pure aqueous medium

doi:10.1016/j.tetlet.2011.06.026

Tetrahedron Letters

Volume 52, Issue 32, 10 August 2011, Pages 4218-4220

https://doi.org/10.1016/j.tetlet.2011.06.026 Get rights and content

Abstract

An efficient and practical synthesis of the non-steroidal anti-inflammatory drug (NSAID) ibuprofenamide by catalytic hydration of 2-(4-isobutylphenyl)propionitrile is described. The readily accessible arene-ruthenium(II) complex [RuCl₂(η⁶-C₆Me₆){P(NMe₂)₃}] is used as the catalyst, pure water as the solvent, and microwave irradiation as the heating source.

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Acknowledgments

Financial support from the Spanish MICINN (Projects CTQ2006-08485/BQU, CTQ2010-14796/BQU and CSD2007-00006) is gratefully acknowledged. J.F. thanks MEC of Spain and the European Social Fund (FPU program) for the award of a Ph.D. grant.

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Ibuprofenamide: a convenient method of synthesis by catalytic hydration of 2-(4-isobutylphenyl)propionitrile in pure aqueous medium

Abstract

Graphical abstract

Section snippets

Acknowledgments

N. Engl. J. Med.

Inflammopharmacology

Arch. Int. Med.

N. Engl. J. Med.

J. Physiol. (Paris)

Tetrahedron: Asymmetry

J. Biotechnol.

Appl. Microbiol. Biotechnol.

Appl. Microbiol. Biotechnol.

Nature

J. Int. Med. Res.

Pharmacol. Ther.

Annu. Rev. Pharmacol. Toxicol.

Proc. Natl. Acad. Sci.

J. Clin. Invest.

Eur. J. Med. Chem.

Indian J. Pharm. Sci.

J. Pharm. Sci.

Eur. J. Med. Chem.

Indian J. Pharm. Sci.

Indian J. Pharm. Sci.

Indian J. Pharm. Sci.

Eur. J. Med. Chem.

J. Med. Chem.

J. Med. Chem.

Chinese Chem. Lett.

Indian J. Pharm. Sci.

Int. J. ChemTech Res.

Der Pharma Chemica

Eur. J. Med. Chem.

Drug Delivery

Med. Chem.

Int. J. Pharm. Pharm. Sci.