ArticleStructural insight into the constitutive activity of human orphan receptor GPR12
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Hao Li graduated from Lanzhou University in 2018. He is currently a Ph. D. candidate at iHuman Institute, ShanghaiTech University. His current research focuses on structural biology, especially on GPCRs, using the cryo-EM method, he is also devoted to the research of data reconstruction algorithm of cryo-EM.
Jinyi Zhang obtained her bachelor’s degree from Shandong University in 2017. She is currently a Ph.D. candidate at iHuman Institute, ShanghaiTech University. She is majoring in structural biology. Her current research interest includes the structural and functional studies of GPCRs and cryo-EM single-particle data processing and analysis.
Yanan Yu is a Ph.D. candidate at iHuman Institute, ShanghaiTech University. Her doctoral tutor is Profs. Zhijie Liu and Tian Hua. She is interested in developing pharmacological methods to facilitate the industrial application and drug discovery of GPCRs, which include the chemical sensing receptors and orphan receptors associated with major diseases.
Feng Luo received his Ph.D. degree in 2019 from Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences and worked as a postdoc in Prof. Zhijie Liu’s Lab at, ShanghaiTech University from 2019–2021. His research focuses on studying the precise mechanism of neuronal signal transmission and communication using cryo-EM method.
Zhijie Liu is a full professor at School of Life Science and Technology, the dean of Dadao College, and executive director of iHuman Institute, ShanghaiTech University. He received his Ph.D. degree in Biophysics in 1994 supervised by Prof. Dongcai Liang. His research interest includes human GPCRs especially sensory receptors and orphan GPCRs which are related to cell signal transductions and drug discovery.
Tian Hua is a tenure-track assistant professor at School of Life Science and Technology, ShanghaiTech University. She obtained her Ph.D. degree from the Institute of Biophysics, Chinese Academy of Sciences in 2017. Her research focus is the molecular dissection and mechanistic understanding of taste receptors, and also the investigation into the neurological-related orphan GPCRs from a pharmacological perspective.
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These authors contributed equally to this work.