Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Spectral and thermal study of the ternary complexes of nickel with sulfasalazine and some amino acids
Introduction
Sulfa drugs have attracted special attention for their therapeutic importance as they were used against a wide spectrum of bacterial ailments [1], [2], [3], [4], [5], [6], [7], [8]. Also, some sulfa drugs were used in the treatment of cancer, malaria, leprosy and tuberculosis [4]. Although the complexes of some sulfa drugs have been investigated in the solid state, no much data is reported about their mixed-ligand complexes [8], [9]. The formation and characterization of binary and mixed-ligand complexes, involving iminodiacetic acid and sulfa drugs as sulfadiazine and sulfadiamidine, were investigated [8], [9], [10].
Binary and ternary complexes of transition metals are commonly found in biological media and might play important roles in process as diverse as the catalytic interaction of viruses with bacterial cell walls, the transport and storage of oxygen, etc. [10].
Continuing my pervious studies on the binary complexes of sulfasalazine with Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Ce(IV), Th(IV) and UO2(IV) [11], [12], the present work throws more insight on chelation behavior of sulfasalazine (H3SS) (Scheme 1), through the synthesis and characterization of the nickel(II) ternary system with some amino acids.
Section snippets
Experimental
All chemicals used were of the highest purity grade. They included: sulfasalazine (Sigma), nickel nitrate hexahydrate (BDH), amino acids (Merk) and ammonium hydroxide (Merck).
Sulfasalazine has four ionization constants [10]: 0.62, 2.9, 8.7 and 11.1 corresponding to the deprotonation of the protonated pyridine nitrogen, carboxylic OH, phenolic OH and sulfonamide hydrogen, respectively. The free carboxylic form of sulfasalazine is insoluble in water or ethanol, so that ammonical ethanolic
Results and discussion
The results of the elemental analyses and mass spectrometry data are presented in Table 1. The results obtained are in good agreement with those calculated for the suggested formulae of the complexes (Ni:HSS:AA:4H2O). The molar conductance values in DMF (Table 1) for the complexes were found to be in the range 16.90–32.00 S cm2 mol−1. The relatively low values indicate the non-electrolytic nature of these complexes [11], [14]. This can be accounted for by the satisfaction of the bivalency of
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