Elsevier

Respiratory Medicine

Volume 187, October 2021, 106556
Respiratory Medicine

Galectin-3 as prognostic biomarker in patients with COVID-19 acute respiratory failure

https://doi.org/10.1016/j.rmed.2021.106556Get rights and content
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Highlights

  • Assess the utility of Galectin-3 for prognosis prediction

  • Increased Galectin-3 serum levels are associated with higher risk of death, ICU access and severe ARDS development

  • Galectin-3 can provide important prognostic information in patients with COVID 19 acute respiratory failure

Abstract

Objectives

Galectin-3 is β-galactoside-binding lectin with several roles in immune-inflammatory response. To date, there is no evidence of Galectin-3 role as a prognostic biomarker in COVID-19 disease. The aim of this study is to clarify the prognostic role of Galectin-3 in patients with COVID 19 acute respiratory failure.

Methods

We enrolled 156 consecutive patients with COVID-19 disease. Routine laboratory test, arterial blood gas, chest X-ray or Computed Tomography and Galectin-3 dosage were performed. The primary outcome was to assess Galectin-3 predictive power for 30-day mortality. Secondary outcomes were 30-day Intensive Care Unit admission and Acute Respiratory Distress Syndrome stratification according to Galectin-3 dosage. We performed Mann-Whitney U and Kruskal-Wallis tests for continuous variables comparison. Fisher's exact test or Chi-square test were used for categorical variables analysis. Receiver Operating Characteristic curves estimated Galectin-3 predictive power for the endpoints. With a fixed cut-off of 35.3 ng/ml, Kaplan-Meier with Log-Rank test and Cox Regression were performed to assess mortality and Intensive Care Unit admission risk.

Results

Galectin-3 correlated with many other prognostic predictors tested in our analysis. Moreover, patients with serum levels of Galectin-3 above 35.3 ng/ml had increased risk for mortality, Intensive Care Unit admission and severe Acute Respiratory Distress Syndrome.

Conclusions

Our study demonstrates the role of Galectin-3 as a predictor of mortality, Intensive Care Unit access and ARDS stratification in patients with COVID 19 acute respiratory failure.

Keywords

Inflammation
Lung injury
Viral pneumonia
ARDS
ICU

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