Case report
Inflammatory bowel disease of the lung: The role of infliximab?

https://doi.org/10.1016/j.rmcr.2015.05.012Get rights and content
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Abstract

Pulmonary extra-intestinal manifestations (EIM) of inflammatory bowel disease are well described with a variable incidence. We present a case of Crohn's disease with pulmonary EIM including chronic bronchitis with non-resolving bilateral cavitary pulmonary nodules and mediastinal lymphadenopathy successfully treated with infliximab. Additionally, we present a case summary from a literature review on pulmonary EIM successfully treated with infliximab. Current treatment recommendations include an inhaled and/or systemic corticosteroid regimen which is largely based on case reports and expert opinion. We offer infliximab as an adjunctive therapy or alternative to corticosteroids for treatment of inflammatory bowel disease related pulmonary EIM.

Keywords

Inflammatory bowel disease
Pulmonary extraintestinal manifestations
Infliximab

List of abbreviations

IBD
inflammatory bowel disease
EIM
extra-intestinal manifestations
TNF
tumor necrosis factor

Cited by (0)

These findings have been presented as a poster presentation at Chest in Austin, Texas in October 2014.