Iodine-125 brachytherapyMultiparametric MRI and post implant CT-based dosimetry after prostate brachytherapy with iodine seeds: The higher the dose to the dominant index lesion, the lower the PSA bounce
Section snippets
Methods and materials
Sixty-six patients with a low risk prostate adenocarcinoma have been included in this retrospective analysis.
Results
Patients and treatments’ characteristics are summarized in Table 1, Table 2, according to the presence or absence of a PSA bounce. The median biochemical follow-up was 35.5 months (range, 13.2–72.5) after the PPI. There was no statistically significant difference between clinical and disease characteristics of patients who had a PSA bounce and those who did not. At time of analysis, no biochemical recurrence was observed.
Discussion
PSA bounces remain problematic and unpredictable in the case of localized prostate cancer after prostate brachytherapy. The pathogenesis of the bounce is still a matter of conjecture. Some clinical and dosimetric factors have been correlated with PSA bounces. Prostatitis, related to the insertion of radioactive iodine seeds or needles, younger age, the presence of benign prostatic hyperplasia (BPH), a large gland, a high D90 or V150 to the whole gland [9], a T2 stage over T1 (i.e. presence of a
Conflicts of interest
None.
Acknowledgements
We want to thank the Canceropole Grand Est for its support and funding and Prof. Jean Marc Cosset (Institut Curie, Paris) for his helpful comments and his wise advises.
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