EditorialFollow the white rabbit: Experimental and computational models of the rabbit heart provide insights into cardiac (patho-) physiology☆
Section snippets
Acknowledgement
We are indebted to Ms. Pia Stroeger for excellent management of this special issue issue. We are also most grateful to all our external reviewers for their critical and constructive assessments that helped to improve the quality of the focused issue. The editors acknowledge financial support by Deutsche Forschungsgemeinschaft, European Research Council, British Heart Foundation, and Deutsche Stiftung für Herzforschung.
References (28)
- et al.
Computational rabbit models to investigate the initiation, perpetuation, and termination of ventricular arrhythmia
Prog. Biophys. Mol. Biol.
(2016) - et al.
Rabbit models as tools for preclinical cardiac electrophysiological safety testing: importance of repolarization reserve
Prog. Biophys. Mol. Biol.
(2016) - et al.
Rabbit models to study atherosclerosis and its complications- transgenic vascular protein expression in vivo
Prog. Biophys. Mol. Biol.
(2016) - et al.
The potential impact of new generation transgenic methods on creating rabbit models of cardiac diseases
Prog. Biophys. Mol. Biol.
(2016) - et al.
Rabbit-specific computational modelling of cardiac cell electrophysiology: using populations of models to explore variability in the response to ischemia
Prog. Biophys. Mol. Biol.
(2016) Disturbances of cardiac wavelength and repolarization precede Torsade de Pointes and ventricular fibrillation in Langendorff perfused rabbit hearts
Prog. Biophys. Mol. Biol.
(2016)- et al.
Intramural multisite recording of transmembrane potential in the heart
Biophys. J.
(2001 Nov) - et al.
Technical advances in studying cardiac electrophysiology - role of rabbit models
Prog. Biophys. Mol. Biol.
(2016) - et al.
Images as drivers of progress in cardiac computational modelling
Prog. Biophys. Mol. Biol.
(2014) - et al.
Transgenic rabbit models to investigate the cardiac ion channel disease long QT syndrome
Prog. Biophys. Mol. Biol.
(2016)
Is heart size a factor in ventricular fibrillation? Or how close are rabbit and human hearts?
Heart Rhythm
Rabbit as a model for studies of cardiac mechano-electric and mechano-mechanical coupling
Prog. Biophys. Mol. Biol.
Cardiac mechano-electric coupling research: fifty years of progress and scientific innovation
Prog. Biophys. Mol. Biol.
Electron tomography of rabbit cardiomyocyte three-dimensional ultrastructure
Prog. Biophys. Mol. Biol.
Cited by (6)
Nano-scale morphology of cardiomyocyte t-tubule/sarcoplasmic reticulum junctions revealed by ultra-rapid high-pressure freezing and electron tomography
2021, Journal of Molecular and Cellular CardiologyCitation Excerpt :To that end, lagomorphs may offer a more relevant model for translational cardiac research. This ranges from responsiveness to pathological processes (such as myocardial ischaemia) and pharmacological interventions, to ion channel and transporter distribution, features of the action potential, mechanisms of Ca2+ homeostasis, and appearance of the TT network [14–17]. At this time however, rabbit cardiomyocyte dyad ultrastructure remains relatively unexplored at the nanometre scale.
Interregional electro-mechanical heterogeneity in the rabbit myocardium
2017, Progress in Biophysics and Molecular BiologyCitation Excerpt :To investigate the mechanisms underlying physiological electro-mechanical heterogeneities, species closely mimicking human cardiac physiology have to be utilized. The rabbit is such a species, showing pronounced similarities to humans in terms of the ‘relative size’ of electrophysiological and structural cardiac characteristics (Panfilov, 2006), ion currents determining action potential (AP) properties (Nerbonne, 2000), responses to electrophysiological and pharmacological interventions (Valentin et al., 2004), regional contractile and diastolic behaviour (Jung et al., 2012), and cardiac mechano-electrical coupling mechanisms (Quinn et al., 2014) (reviewed in PBMB issue on “rabbit models in heart research” by Odening and Kohl, 2016). In the healthy rabbit heart some evidence has been put forward to show that APD, ICa,L and the repolarizing currents IKs and IKr are heterogeneous in an apico-basal pattern (Cheng et al., 1999; Yang et al., 2012), but conflicting studies exist as well (Mantravadi et al., 2007).
Transgenic rabbit models for cardiac disease research
2022, British Journal of PharmacologyTransgenic Animal Models of Cardiac Channelopathies: Benefits and Limitations
2018, Cardiac and Vascular Biology
- ☆
Lewis Carrol, Alice in Wonderland.