Behavioural NeuroscienceResearch PaperAMPA receptor subunit GluR1 downstream of D-1 dopamine receptor stimulation in nucleus accumbens shell mediates increased drug reward magnitude in food-restricted rats
Section snippets
Subjects and surgical procedures
All subjects were male Sprague–Dawley rats (Taconic Farms, Germantown, NY, USA) weighing 350–400 g at the time of arrival in the central animal facility where they were housed in individual plastic cages, with free access to Purina rat chow (St. Louis, MO, USA) and water unless otherwise noted. The animal room was maintained on a 12-h light/dark cycle, with lights on at 07:00 h. Approximately half the subjects in each experiment were placed on a chronic food restriction regimen whereby daily
Experiments 1 and 2: GluR1 phosphorylation under basal and stimulated conditions in AL and FR rats
Following vehicle administration, NAc tissue samples obtained from AL and FR rats did not differ in abundance of total GluR1 protein, phospho-Ser845 (Fig. 1), or phospho-Ser831 GluR1 (Fig. 2). Systemic administration of the D-1 DA receptor agonist, SKF-82958 (1.0 mg/kg i.p.), increased GluR1 phosphorylation on Ser845 in NAc (F1,16=24.4, P<.001). Feeding groups differed (F1,16=7.1, P<.02), and an interaction between drug treatment and feeding condition (F1,16=4.8, P<.05), followed by Fisher's
Discussion
The enhanced rewarding effects of abused drugs in FR animals have been demonstrated in self-administration, conditioned placed preference, and ICSS paradigms (Carroll and Meisch, 1984, Bell et al., 1997, Cabeza de Vaca and Carr, 1998, Cabeza de Vaca et al., 2004, Carr et al., 2000). The mechanistic importance of NAc neuroadaptations downstream of D-1 DA receptor stimulation in these behavioral effects is suggested by findings that FR enhances SKF-82958-induced activation of several
Acknowledgments
Supported by DA003956 (KDC) and MH067229 (EBZ) from NIH, and a seed grant in the Center of Excellence on Addiction from the New York University Langone Medical Center.
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Homeostatic regulation of reward via synaptic insertion of calcium-permeable AMPA receptors in nucleus accumbens
2020, Physiology and BehaviorCitation Excerpt :Microinjection of Naspm into NAc shell reversed the enhanced rewarding effects of SKF-82958 (D1/D5R agonist) [30] and d-amphetamine [150], and reversed the enhanced locomotor-activating effect of SKF-82958 in FR subjects [145]. Naspm had no effect on the rewarding or locomotor-activating effects of the D2-like (D2/D3R) agonist, quinpirole [30,145]. The significance of a synaptic population of CP-AMPARs lies in distinct properties they possess relative to other AMPAR types, including larger single channel conductance, faster kinetics, and triggering of postsynaptic signaling cascades that depend on Ca2+ [115].
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2016, Brain Research BulletinCitation Excerpt :There is extensive research providing support for the regulation of drug effects by mechanisms of energy balance and body weight regulation (Daws et al., 2011; DiLeone, 2009; Marinelli et al., 1996). Studies in rats have shown that food restriction increases sensitivity to the rewarding properties of drugs of abuse (Berthoud and Zheng, 2012; Cabeza de Vaca and Carr, 1998; Carr et al., 2010, 2000). Therefore, it is plausible that excessive weight loss after RYGB exacerbates sensitivity to drug reward.